Journals / Türk Biyokimya Dergisi / 2021 / Cilt: 46 - Sayı: 2

Determination of vitamin 25-hydroxyvitamin D deficiency and insufficiency cut-off values in children

Çocuklarda 25-hidroksivitamin D eksiklik ve yetersizlik sınır değerlerinin araştırılması

Pages
183–189
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

By age sub group, the vitamin (25-OHD) deficiency and insufficiency cut-off values are 21–31, 15–21 and 13–18 ng/mL for those 0–2, 3–6 and 7–18 years, respectively.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: There is no consensus on the lower and upper limits of 25-hydroxyvitamin D (25-OHD) deficiency and insufficiency.
📊
Key Findings & Data:We determined the (25-OHD) deficiency and insufficiency cut-off values in children.
💡
Conclusion & Impact:By age sub group, the vitamin (25-OHD) deficiency and insufficiency cut-off values are 21–31, 15–21 and 13–18 ng/mL for those 0–2, 3–6 and 7–18 years, respectively.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: There is no consensus on the lower and upper limits of 25-hydroxyvitamin D (25-OHD) deficiency and insufficiency. We determined the (25-OHD) deficiency and insufficiency cut-off values in children. Methods: The study examined 422 children aged 0–18 years old whose simultaneous parathormone (PTH) and (25-OHD) levels were measured at the paediatric outpatient clinics of our tertiary research hospital in Istanbul from January 1, 2014 to December 31, 2017. Those without chronic diseases were included in this cross-sectional retrospective study. Results: We found that the average serum (25-OHD) level was lower in girls. There were negative correlations be tween (25-OHD) and PTH and age. The level that decreased PTH below the upper level was 14.42 ng/mL and the 25(OH) D level that decreased it to the lowest limit was 26.61 ng/ mL. The (25-OHD) level that caused maximum suppression of PTH was 22.5 ng/mL. Conclusions: The vitamin (25-OHD) deficiency (lowest value) and insufficiency (range) cut-off should be 14–23 ng/mL for children living in Istanbul. By age sub group, the vitamin (25-OHD) deficiency and insufficiency cut-off values are 21–31, 15–21 and 13–18 ng/mL for those 0–2, 3–6 and 7–18 years, respectively.

Özet

Giriş: 25 hidroksivitamin D (25-OHD) eksikliği ve yetersi zliğinin alt ve üst sınırları konusunda fikir birliği yoktur. Biz de çocuklarda, (25-OHD)’ nin eksiklik ve yetersizlik sınır değerlerini araştırdık. Gereç ve Yöntem: Çalışma, 1 Ocak 2014 ile 31 Aralık 2017 tarihleri arasında, İstanbul’ daki 3. basamak hastanemizin çocuk polikliniğine başvuran ve aynı anda Parathormon ve (25-OHD); bakılan, 0–18 yaş arası 422 çocuk ile gerçekleş tirildi. Geriye dönük kesitsel çalışmamıza, kronik hastalığı olanlar dahil edilmedi. Bulgular: Ortalama serum (25-OHD) düzeyini kızlarda daha düşük bulduk. (25-OHD) ile Parathormon ve yaş arasında negatif ilişki vardı. Parathormonunu, normal değerlerinin üst sınırının altına inmesini sağlayan (25-OHD) düzeyi 14.42 ng/mL ve alt sınırının altına inme sini sağlayan (25-OHD) düzeyi 26.61 ng/mL dir.Par athormonun en çok baskılanmasına neden olan (25-OHD) düzeyi 22.5 ng/mL dir. Sonuç: İstanbul’ da yaşayan çocuklar için, (25-OHD) eksiklik alt sınırı ve yetersizlik aralığı 14–23 ng/ml olmalı dır. Yaş gruplarına göre (25-OHD) eksiklik ve yetersizlik sınır değerleri 0–2, 3–6 ve 7–18 yaşlar için sırasıyla; 21–31, 15–21 ve 13–18 ng/mL dir.

🔖

Cite This Article

KOLDAŞ, M., ELEVLİ, M., ŞAHİN, K., AVCI, R., ÇOŞKUN, C., YILMAZ, S. K. (2022). Determination of vitamin 25-hydroxyvitamin D deficiency and insufficiency cut-off values in children. Türk Biyokimya Dergisi, Cilt: 46 - Sayı: 2, 183–189. https://ajindex.com/articles/620694

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. 1 Zeni SN, Luz M, Martin de Portela P. Update on low levels of 25 (OH) D and outcomes: our experience. In Lerner V, Chanoch M, editors. DNLM: 1. Vitamin D deficiency-complications. ISBN: 978- 1-61470-964-0. e-Book.©. Hauppauge, NY: Nova Science Publishers, Inc
  2. Demiral M, Sırmagül B, Kirel B. Vitamin D levels in children admitted to the endocrine outpatient clinic. J Curr Pediatr 2016
  3. 60–6. 3. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008
  4. 398–417. 4. Craig F, Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD. Global consensus recommendations on prevention and management of nutritional rickets. Res Paediatr 2016
  5. 83–106. 5. Yetim A, Tıkız C, Baş F. Pravelance of vitamin D and B12 deficiency in adolescence. J Child/Cocuk Dergisi 2017
  6. 24–9. 6. Razzaghy AM, Shakiba M. Assessment of vitamin D status in healthy children and adolescents living in Tehran and its relation to iPTH, gender, weight and height. Ann Hum Biol 2010
  7. Smith M. Seasonal, ethnic and gender variations in serum vitamin D3 levels in the local population of Peterborough. Biosci Horizons 2010
  8. 124–31. 8. Al Shaikh AM, Abaalkhail B, Soliman A, Kaddam I, Aseri K, Al Saleh Y. Prevalence of vitamin D deficiency and calcium homeostasis in Saudi children. J Clin Res Pediatr Endocrinol 2016
  9. 461–7. 9. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium
  10. Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academy Press
  11. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP. Endocrine Society. Evaluation, treatment and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011
  12. 1911–30. 11. Society for Adolescent Health and Medicine. Recommended vitamin D intake and management of low vitamin D status in adolescents: a position statement of the society for adolescent health and medicine. J Adolesc Health 2013
  13. 801–3. 12. Bouillon R. Vitamin D: photosynthesis, metabolism, and action to clinical applications. In: Jameson JL, et al., editors. Endocrinology: adults and pediatric, 7th ed. Philadelphia, PA: Saunders
  14. 1018–37. 13. Francis RM, Aspray TJ, Bowring CE, Fraser WD, Gittoes NJ, Javaid MK, et al. National osteoporosis soci