Journals / Türk Anestezi ve Reanimasyon Dergisi / 2003 / Cilt: 31 - Sayı: 6

Acute normovolemic hemodilution in coronary artery bypass surgery: Effects on inflammatory response

Koroner arter baypas ameliyatında akut normovolemik hemodilüsyon. Enflamatuar yanıta etkisi

Pages
296–302
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The amount of transfused allogenic blood was lower in Group I compared to group II (p

📌 3 Key Takeaways

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Objective & Hypothesis:Acute normovolemic hemodilution is the removal of the blood from patients before or shortly after induction of anesthesia, and simultaneous replacement with acellular fluid, that is crystalloid or colloid and retransfusion of removed blood if needed.
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Key Findings & Data:After Ethics Committee approval 40 patients undergoing coronary artery bypass surgery were divided into two groups randomly.
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Conclusion & Impact:The amount of transfused allogenic blood was lower in Group I compared to group II (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Acute normovolemic hemodilution is the removal of the blood from patients before or shortly after induction of anesthesia, and simultaneous replacement with acellular fluid, that is crystalloid or colloid and retransfusion of removed blood if needed. In this study we aimed to evaluate the effects of acute normovolemic hemodilution on and inflammatory response in patients undergoing coronary artery bypass surgery. After Ethics Committee approval 40 patients undergoing coronary artery bypass surgery were divided into two groups randomly. After induction of anesthesia, one or two units of blood were drawn from the Group I (n=20) until the hematocrit values became lesser than < 35%. At the same time, volume replacement was achieved with same amount of colloid infusion from peripheral vein. Any additional procedure was not done to the control group (Group II, n=20). Alanine transaminase, aspartate transaminase, lactate dehydrogenase, creatine kinase MB, creatine phosphokinase, g-glutamyl transferase, complement 3a, complement 4a, ferritin, transferrin, nitric oxide, C-reactive protein and haptoglobulin levels were measured before induction, after operation, postoperative 6th and 24th hours. The amount of transfused allogenic blood was lower in Group I compared to group II (p

Özet

Akut normovolemik hemodilüsyon anestezi indüksiyonundan hemen önce veya sonra olgudan kanın alınarak, eş zamanlı olarak kolloid ya da kristalloid gibi hücre içermeyen solüsyonlarla replase edilmesi ve gerekli olduğunda hastaya geri verilmesidir. Bu çalışmada akut normovolemik hemodilüsyonun koroner arter bypass ameliyatı geçirecek olgularda enflamatuar yanıta etkilerini değerlendirmeyi amaçladık. Etik Kurul onayı alındıktan sonra koroner arter by-pass ameliyatı geçirecek 40 olgu rasgele iki gruba ayrıldı. Anestezi indüksiyonundan sonra Grup I (n=20)'den hematokrit < % 35 oluncaya kadar bir veya iki ünite kan alındı. Alınan kan periferik venden eş zamanlı eşit miktarda kolloid sıvı ile replase edildi. Grup II (n=20)'ye ek işlem yapılmadı. Alanin transaminaz, aspartat transaminaz, laktat dehidrogenaz, kreatin kinaz MB, kreatin fosfokinaz, g-glutamil transferaz, kompleman 3a, kompleman 4a, ferritin, transferrin, nitrik oksit, C-reaktif protein, haptoglobulin seviyeleri preoperatif, ameliyat sonu, postoperatif 6. ve 24. saatlerde ölçüldü. Transfüze edilen allojenik kan miktarı Grup I'de Grup II'ye göre daha düşüktü (p

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Cite This Article

SEZGİN, N., KARAASLAN, K., DOĞAN, Z., BUT, A. K., ERSOY, M. Ö., DURMUŞ, M. (2022). Acute normovolemic hemodilution in coronary artery bypass surgery: Effects on inflammatory response. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 31 - Sayı: 6, 296–302. https://ajindex.com/articles/620261

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