Journals / Türk Anestezi ve Reanimasyon Dergisi / 2003 / Cilt: 31 - Sayı: 8

Prolonged neuromuscular block and hyperglycemia due to pseudocholinesterase deficiency (Two cases reports)

Psödokolinesteraz Eksikliğine Bağlı Uzamış Nöromusküler Blok ve Hiperglisemi (İki Olgu)

Pages
426–429
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Hyperglycemia due to pseudocholinesterase deficiency, and relation between pseudocholinesterase and glucose were discussed in prolonged neuromuscular block cases according to the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pseudocholinesterase is an enzyme functioning in the metabolism of lipids and lipoproteins and ıt is important in the degradation of succinylcholine and mivacurium.
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Key Findings & Data:In this report, we presented two cases who had hyperglycemia with concomitant prolongation of the neuromuscular block due to pseudocholinesterase deficiency that was not diagnosed prior to operation.
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Conclusion & Impact:Hyperglycemia due to pseudocholinesterase deficiency, and relation between pseudocholinesterase and glucose were discussed in prolonged neuromuscular block cases according to the literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Pseudocholinesterase is an enzyme functioning in the metabolism of lipids and lipoproteins and ıt is important in the degradation of succinylcholine and mivacurium. In this report, we presented two cases who had hyperglycemia with concomitant prolongation of the neuromuscular block due to pseudocholinesterase deficiency that was not diagnosed prior to operation. At the end of the operation, the patients had no return of spontaneous respiration and response to TOF stimulation. In addition, there was temporary hyperglycemia. Hyperglycemia due to pseudocholinesterase deficiency, and relation between pseudocholinesterase and glucose were discussed in prolonged neuromuscular block cases according to the literature.

Özet

Psödokolinesteraz, lipid ve lipoprotein metabolizmasında rol alan, süksinilkolin ve mivakuryumun yıkımını sağlayan önemli bir enzimdir. Bu makalede preoperatif tanı almamış psödokolinesteraz eksikliğine bağlı nöromüsküler (NM) blok uzamasıyla birlikte hiperglisemi gelişen 2 olgu sunuldu. Ameliyat tamamlandıktan sonra spontan solunumu dönmeyen bu hastalarda Train-of-Four (TOF) stimulasyonuna cevabın olmadığı gözlendi. Ayrıca geçici hiperglisemi geliştiği saptandı. Uzamış NM blok olgularında psödokolinesteraz eksikliğine bağlı gelişen hiperglisemi, psödokolinesteraz ile glukoz arasındaki korelasyon literatürle birlikte tartışıldı.

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Cite This Article

ÖZER, E., ÇELİK, M., ÖNER, Ü., SARIMEHMETOĞLU, F., PİRBUDAK, L. (2022). Prolonged neuromuscular block and hyperglycemia due to pseudocholinesterase deficiency (Two cases reports). Türk Anestezi ve Reanimasyon Dergisi, Cilt: 31 - Sayı: 8, 426–429. https://ajindex.com/articles/620231

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References (16)

  1. Ostergaard D, Ibsen M, Skovgaard L, Viby-Mogensen J: Plasma cholinesterase activity and duration of action of mivacurium in pbenotypically normal patients. Acta Anaesthesiol Scand 2002; 46:679-683
  2. Rosenman KD, Guss PS: Prevalance of congenital deficiency İn serum cholinesterase. Arch Environ Health 1997; 52:42-44
  3. Petersen RS, Bailet PL, Kalameghan R: Prolonged neuro-muscular block after mivacurium. Anaesth Analg 1993; 76:194-196
  4. Goudsouzian NG, Hollander AA, Viby-Mogensen J: Prolonged neuromuscular block from mivacurium in two patients with cholinesterase deficiency. Anaesth Analg 1993; 77:183-185
  5. Matsui T, Kimura I, Kimum M: Increase in the activities of plasma pseudocholinesterase dependent on the blood glucose level and its relation lo the hypersensitivity to acetylcholine in straited muscles of KK-CAy mice with diabetes. Jpn J Pharmacol 1990; 54:97-103
  6. Wong TKM, Chen C, Liou SC, Lee YH, Huang CS: Prolonged neuromuscular block with mivacurium in a patient with cholinesterase deficiency. J Formos Med Assoc 2000; 99:655-658
  7. Fox MH, Hunt PCW: Prolonged neuromuscular block associated with mivacurium. Br J Anaesth 1995; 74:237-238
  8. Sockalinyan I, Green DW: Mivacurium-induced prolonged neuromusculer block. Br J Anaesth 1995; 74:234-236
  9. Cook DR, Stiller RL, Weakly JN: In vitro metabolism of mivacurium chloride (BW B1090 U) and succinylcholine. Anesth Analg 1989; 68:452-456
  10. Trevien V, Lienhart A,Just B, et al: Effect of neostigmin at different levels of mivacurim-induced neuromusculer blockade. Acta Anesthesiol Scand 1995; 39:66-69
  11. Jensen FS, Skovgaard LT, Viby Mogensen J: Identification of human plasma cholinesterase variants in 6.688 individuals using biochemical analysis. Acta Anaesthesiol Scand 1995;39:157-162
  12. Morgan EG, Mikhail MS, Murray MJ: Clinical Anesthesiology. Third ed. McGraw-Hill Companies. USA 2002; p.178-566
  13. Kayhan Z: Klinik Anestezi
  14. Baskı. Logos Yayıncılık. İstanbul 1997;p.354-77
  15. Oreskovic K, Kunec-Vajic E: Pseudocholinesterase in alloxan diabetic rats. Res Commum Chem Pathol Pharmacol 1992; 78:117-120
  16. Annapurna V, Senciall I, Davis AJ, Kutty KM: Relationship between serum pseudocholinesterase and triglycerides in experimentally induced diabetes mellitus rats. Diabetologia 1991; 34:320-324.