AI Summary & Key Takeaways
AI InsightThe times of to spontaneous breathing, eye opening with verbal command, extubation, modified Aldrete score ≥ 9 and adverse effects were also recorded.The mean arterial pressure at intubation, skin incision, burr hole opening, removal of bone flap, replacement of bone flap, at the end of surgery and the heart rate at skin incision, replacement of bone flap were found to be significantly higher in the fentanyl group when compared with the remifentanil group (p
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Abstract
In this study, we aimed to compare of effects of remifentanil and fentanyl on hemodynamic parameters and postoperative return of consciousness following the removal of supratentorial space occupying lesions.After Research Ethics’ Committee approval and written informed consent from patients, 25 ASA physical status I-III adult patients were randomized into two groups Group I (n= 12) received remifentanil 1 µg kg-1 for induction and 0.15 µg kg-1 min-1 for maintenance and Group II (n=13) received fentanyl 2 µg kg-1 for induction and 0.03 µg kg-1 min-1 for maintenance. In both groups intubation was done following vecuronium 0.1 µg mg kg-1 and propofol 2 µg mg kg-1 and anaesthesia was maintained with propofol 50-200 µg kg-1 min-1, O2 40%, N2O 60 %. Mean arterial pressure and heart rate were recorded one minute after the basal measurement, entubation intubation, application of skull pins, skin incision, burr hole opening, removal of bone flap, replacement of bone flap, closure of skin and at the end of surgery. The times of to spontaneous breathing, eye opening with verbal command, extubation, modified Aldrete score ≥ 9 and adverse effects were also recorded.The mean arterial pressure at intubation, skin incision, burr hole opening, removal of bone flap, replacement of bone flap, at the end of surgery and the heart rate at skin incision, replacement of bone flap were found to be significantly higher in the fentanyl group when compared with the remifentanil group (p
Özet
Bu araştırmada supratentoriyal yer kaplayan oluşumlar nedeniyle kraniyotomi yapılan hastalarda, remifentanil ve fentanilin, intraoperatif hemodinami ve postoperatif erken dönem uyanıklılık üzerine etkilerinin karşılaştırılması amaçlandı. Etik kurul izni ve yazılı hasta onamından sonra, ASA I-III grubunda, elektif kraniyotomi planlanan 25 erişkin hasta rasgele 2 gruba ayrıldı. İndüksiyonda R grubuna (n=12) 1 mg kg-1, idamede 0.15 mg kg-1 dk-1 remifentanil, F grubuna (n=13) indüksiyonda 2 mg kg-1, idamede 0.03 mg kg-1 dk-1 fentanil uygulandı. Her iki grupta vekuronyum 0.1 mg kg-1 ve propofol 2 mg kg-1 ile entübasyon gerçekleştirilerek, idame propofol 50-200 mg kg-1 dk-1, % 40 O2 ve % 60 N2O ile sağlandı. Bazal, entübasyon, çivili başlık takılması, cerrahi kesi, burr-hole açılması, kemik flep kaldırılması, kemik flep yerleştirilmesi, cilt kapatılması ve cerrahi sonu dönemlerinden 1 dk. sonra ortalama arter basıncı ve kalp atım hızı değerleri; spontan solunumun başlama, solunumun yeterli hale gelme, komutla göz açma, ekstübasyon ve modifiye Aldrete skorunun ≥ 9 ulaşma süreleri ve yan etkiler kaydedildi.Fentanil grubunda, entübasyon, cerrahi kesi, burr-hole açılması, kemik flep kaldırılması, kemik flep yerleştirilmesi ve cerrahi sonu ortalama arter basıncı ile cerrahi kesi ve kemik flep yerleştirilmesi kalp atım hızı, remifentanil grubuna göre anlamlı olarak yüksek bulundu (p