Journals / Türk Anestezi ve Reanimasyon Dergisi / 2005 / Cilt: 33 - Sayı: 4

Comparison of the preemptive MgSO4 and remifentanil and perioperative hemodynamics and postoperative pain in total abdominal hysterectomy

Total abdominal histerektomi operasyonlarında MgSO4 ile remifentanilin hemodinami ve postoperatif ağrı üzerine etkilerinin karşılaştırılması

Pages
298–306
Publication Date
2022-11-05
DOI
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Postoperative pain scores, morphine consumption and rescue medication requirements were lower in the MgSO4 group while sedation scores and patient satisfaction were higher (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Administration of analgesia prior to surgical stimulus has been proposed to inhibit sensitivity to surgery at the spinal level and has been referred to as preemptive analgesia.
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Key Findings & Data:In our study we compared the effects of MgSO4 and remifentanil on intraoperative analgesic requirements and postoperative pain.Materials and Methods: Forty patients, ASA I-II, between 30-60 years age undergoing total abdominal hysterctomy were randomly assigned to two groups.Prior to induction Group M received 30 mg kg-1 iv MgSO4 and Group R received 1 µg kg-1 iv bolus remifentanil.
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Conclusion & Impact:Postoperative pain scores, morphine consumption and rescue medication requirements were lower in the MgSO4 group while sedation scores and patient satisfaction were higher (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Administration of analgesia prior to surgical stimulus has been proposed to inhibit sensitivity to surgery at the spinal level and has been referred to as preemptive analgesia. In our study we compared the effects of MgSO4 and remifentanil on intraoperative analgesic requirements and postoperative pain.Materials and Methods: Forty patients, ASA I-II, between 30-60 years age undergoing total abdominal hysterctomy were randomly assigned to two groups.Prior to induction Group M received 30 mg kg-1 iv MgSO4 and Group R received 1 µg kg-1 iv bolus remifentanil. After same anaesthetic induction, during surgery group M received 10 mg kg-1 h-1 MgSO4 infusion and, group R received 0.25 µg kg-1 min-1 remifentanil infusion. Postoperatively all groups received patient control analgesia (PCA) morphine by a standard protocol.Results: No intraoperative change in haemodynamics was noted in the M group. There was no significant difference in heartrate (HR) between the groups but the remifentanil group was more hypotensive (p< 0.05). The intraoperative analgesic requirement was not different between the groups. Postoperative pain scores, morphine consumption and rescue medication requirements were lower in the MgSO4 group while sedation scores and patient satisfaction were higher (p

Özet

Amaç: Analjezinin cerrahi uyarıdan önce verilmesi, cerrahi uyarıya spinal duyarlılığı inhibe ederek postoperatif ağrıyı azaltması preemptif analjezi olarak bilinir. Çalışmamızda MgSO4 ve remifentanilin, intraoperatif analjezik gereksinimi ve postoperatif ağrı üzerine olan etkilerini karşılaştırdık.Gereç ve Yöntem: ASA I-II, 30-60 yaş arası total abdominal histerektomi yapılacak 40 hasta, rastgele iki gruba ayrıldı. İndüksiyon öncesi, Grup M'ye 30 mg kg-1 MgSO4 iv, Grup R'ye 1 µg kg-1 remifentanil iv bolus uygulandı. Standart anestezi indüksiyonunu takiben, Grup M'ye 10 mg kg-1 sa-1'den MgSO4, Grup R'ye 0.25 µg kg-1 dk-1'dan remifentanil infüzyonuna başlandı. Postoperatif dönemde ise, morfin ile hasta kontrollü analjezi yöntemi uygulandı.Bulgular: Kalp hızı bakımından gruplar arasında fark yoktu. ortalama arter basıncı açısından ise MgSO4 grubu hemodinamik olarak daha stabil iken remifentanil grubu daha hipotansifti. İntraoperatif analjezik gereksiniminde, gruplar arasında fark yoktu. Postoperatif dönemde ağrı skorları, morfin tüketimleri, ek analjezik gereksinimleri MgSO4 grubunda daha düşük, sedasyon skorları ve hasta memnuniyeti daha yüksekti (p

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Cite This Article

KARAMAN, S., FIRAT, V., UYAR, M., GÜNÜŞEN, İ. (2022). Comparison of the preemptive MgSO4 and remifentanil and perioperative hemodynamics and postoperative pain in total abdominal hysterectomy. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 33 - Sayı: 4, 298–306. https://ajindex.com/articles/620132

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References (16)

  1. Kehlet H. Postoperative pain relief-what is the issue?. Br J Anaesth 1994; 72:375
  2. Mitchell VD, Raja SN. Preemptive Analgesia: Clinical Studies. Benzon Raja Barsook, Molloy Strichartz (eds): Essentials of Pain Medicine and Regional Anesthesia: Philadelphia, Pennsylvania: 1999, 140-143
  3. Niv D, Devor M. Preemptive Analgesia: Can it prevent subacute postoperative pain. P.Prithvi Raj (ed). Practical Management of Pain. Third edition. St. Louis, Missouri: 1999,986-1002
  4. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence. Pain 1993; 52:259-285
  5. Koinig H, Wallner T, Marhofer P, et al. Magnesium sulfate reduces intra and postoperative analgesic requirements. Anesth Analg 1998; 87:206-210
  6. Woolf CJ, Thompson WN. The induction and maintenance of central sensitization is dependent on NMDA receptor activation: implications for the treatment of post-injury pain hypersensitivity states. Pain 1991; 44:293-299
  7. James MFM, Beer RE, Esser JD, et al. Intravenous magnesium sulfate inhibits catecholamine release associated with tracheal intubation. Anesth Analg 1989; 68:772-776
  8. Lipman J, Jams MFM, Erskine J, Plit ML, et al. Autonomic dysfunction in severe tetanus: magnesium sulphate as an adjunct to deep sedation. Crit Care Med 1987;15:987-988
  9. Sanchez-Capuchino A, Me Conachie I. Perioperative effect of major gastrointestinal surgery on serum magnesium. Anaesthesia 1994; 49:912-914
  10. Maurset A, Skoglund LA, Hustveit O. Comparison of ketamine and pethidine in experimental and postoperative pain. Pain 1989; 36:37-41
  11. Puri GD, Marudhachalam KS, Chari P, Suri RK. The effect of magnesium sulphate on hemodynamics and its efficacy in attenuating the response to endotracheal intubation in patient whit coronary artery disease. Anesth Analg 1998; 87:808-811
  12. Kara H, Şahin N, Ulusan V, Aydoğdu T. Magnesium infusion reduces perioperative pain. Eur J of Anaesthesiol 2002; 19:52-56
  13. Wilder-Smith CH, Knöpfli R, Wilder-Smith OHG. Perioperative magnesium infusion and postoperative pain. Acta Anaesthesiol Scand 1997; 41:1023-1027
  14. Tramer MR, Schneider J, Marti RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anesthesiology 1996; 84:340-347
  15. Seong-Hoon KO, Hye-Rin Lim, Dong-Chan Kim et al. Magnesium sulfate does not reduce postoperative analgesic requirement. Anesthesiology 2001; 95:640-646
  16. Joo G, Horvath G, Klimsche W, et