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Journals / Türk Anestezi ve Reanimasyon Dergisi / 2005 / Cilt: 33 - Sayı: 1

The effect of N-acetylcysteine treatment to prevent the progression of multiple organ failure

N-asetil sistein tedavisinin çoklu organ yetmezliği gelişmesini önlemedeki yeri

Seda B. AKINCI
İ. Aydın ERDEN
Ülkü AYPAR
Meral KANBAK
Pages
76–81
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Two patients were withdrawn because of ICU stay

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: We investigated whether prolonged infusion of the oxygen free radical scavenger N-acetylcysteine (NAC) started immediately after admission to intensive care unit (ICU) could ameliorate the development or progression of multiple organ failure (MOF).Materials and Methods: After receiving local ethics committee approval, 26 patients enrolled into a prospective, randomized, double-blinded, placebo-controlled trial.
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Key Findings & Data:Patients were allocated to recieve either NAC in 5 % dextrose 40 mg/kg/day in four divided doses or the same volume of. 5 % dextrose.
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Conclusion & Impact:Two patients were withdrawn because of ICU stay
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: We investigated whether prolonged infusion of the oxygen free radical scavenger N-acetylcysteine (NAC) started immediately after admission to intensive care unit (ICU) could ameliorate the development or progression of multiple organ failure (MOF).Materials and Methods: After receiving local ethics committee approval, 26 patients enrolled into a prospective, randomized, double-blinded, placebo-controlled trial. Patients were allocated to recieve either NAC in 5 % dextrose 40 mg/kg/day in four divided doses or the same volume of. 5 % dextrose. Two patients were withdrawn because of ICU stay

Özet

Amaç: Çalışmamızda serbest oksijen radikal tutucu N-asetil sisteinin (NAS) yoğun bakım hastalarında, hemen başlanan, uzun süreli infüzyonunun, çoklu organ yetmezliği gelişmesini önlemedeki yerini araştırmayı amaçladık.Gereç ve Yöntem: Fakülte etik komite izni alındıktan sonra prospektif, randomize, çift kör, plasebo kontrollü çalışmaya 26 hasta alındı. Hastalar % 5 dekstroz solüsyonu içinde 40 mg/kg/gün NAS veya aynı hacimde % 5 dekstroz solüsyonu 4 eşit dozda alacak şekilde rasgele gruplandırıldı.İki hasta yoğun bakım yatış süreleri 24 saatten kısa olduğu için çalışma dışı bırakıldı.Tedavinin organ fonksiyonları üzerine etkisi Sequential Organ Failure Assessment (SOFA) skorlama sistemi ile hasta kabulünde ve hergün değerlendirildi. İstatistiksel analiz için Ki-kare ve Mann Whithney U testleri kullanıldı.Bulgular: NAS grubunda, maksimum SOFA koagülasyon skoru kontrol grubundan daha yüksek bulundu (p

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Cite This Article

AKINCI, S. B., ERDEN, İ. A., AYPAR, Ü., KANBAK, M. (2022). The effect of N-acetylcysteine treatment to prevent the progression of multiple organ failure. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 33 - Sayı: 1, 76–81. https://ajindex.com/articles/620108

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