Journals / Türk Anestezi ve Reanimasyon Dergisi / 2005 / Cilt: 33 - Sayı: 1

The effects of dexmedetomidine on sevoflurane minimum alveolar concentrations

Deksmedetomidinin sevofluran minimum alveolar anestezik konsantrasyonlarına etkisi

Pages
43–47
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were no significant differences regarding the MACEI and MAC of sevoflurane between groups.Conclusion: We conclude that: dexmedetomidine has no-significant affect on sevoflurane MAC, during endotracheal intubation and skin incision.in this group of patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Dexmedetomidine is an a2-adrenoreceptor agonist and that reduces the anaesthetic requirement during total intravenous anaesthesia and inhalational anaesthesia.
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Key Findings & Data:Both subgroups included 30 patients who were scheduled for elective surgery.
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Conclusion & Impact:There were no significant differences regarding the MACEI and MAC of sevoflurane between groups.Conclusion: We conclude that: dexmedetomidine has no-significant affect on sevoflurane MAC, during endotracheal intubation and skin incision.in this group of patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Dexmedetomidine is an a2-adrenoreceptor agonist and that reduces the anaesthetic requirement during total intravenous anaesthesia and inhalational anaesthesia. The purpose of this study was to evaluate whether dexmedetomidine administered before anesthesia induction reduces sevoflurane minimum alveolar anaesthetic concentration for endotracheal intubation (MACEI) and skin incision (MAC).Materials and Methods: Patients were divided into MACEI-study and MAC-study subgroup. Both subgroups included 30 patients who were scheduled for elective surgery. Patients were not premedicated before induction of anesthesia and randomly assigned to receive iv saline 0.9% (Group I, n=15 in the each study subgroup) or dexmedetomidine 10 µg kg-1 bolus + 1 µg kg-1 h-1 continuous infusion (Group II, n=15 in the each study subgroup).Results: Median and 95 % confidence limits for sevoflurane MACEI were 3.06 (2.89-3.25) and 2.69 (2.52-2.84), and for sevoflurane MAC were 2.21 (2.09-2.34) and 1.96 (1.84-2.09) in groups I and II, respectively. There were no significant differences regarding the MACEI and MAC of sevoflurane between groups.Conclusion: We conclude that: dexmedetomidine has no-significant affect on sevoflurane MAC, during endotracheal intubation and skin incision.in this group of patients.

Özet

Amaç: Dexmedetomidin bir a2-adrenoreseptor agonistidir ve total intravenöz anestezi ve inhalasyon anestezisi sırasında anestezik ihtiyacını azaltır. Bu çalışmanın amacı, anestezi indüksiyonundan önce uygulanan deksmedetomidinin sevofluran minimum alveolar anestezik konsantrasyonunu, endotrakeal entübasyon (MAKEE) ve cilt insizyonu (MAK) için azaltıp azaltmadığını değerlendirmektir.Gereç ve Yöntem: Olgular MAKEE ve MAK çalışma alt gruplarına ayrıldı. İki gruptada elektif cerrahi planlanan 30 olgu çalışmaya dahil edildi. Olgulara anestezi indüksiyonundan önce premedikasyon uygulanmadı ve rastgele iv salin %0.9 (Grup I, n=15 her çalışma alt grubunda) veya dexmedetomidin 10 µg kg-1 bolus + 1 µg kg-1 saat-1 infüzyon (Grup II, n=15 her çalışma alt grubunda) verilmesi planlandı.Bulgular: Grup I ve II'de median ve % 95 güvenilirlik limiti sırası ile sevofluran MAKEE için 3.06 (2.89-3.25) ve 2.69 (2.52-2.84) ve sevofluran MAK'ı için 2.21 (2.09-2.34) ve 1.96 (1.84-2.09) olarak saptandı.Sonuç: Gruplar arasında sevofluran MAKEE ve MAK değerleri açısından anlamlı fark saptanmadı. Bu hasta gurubunda, deksmedetomidinin endotrakeal entübasyon ve cilt insizyonu sırasında MAK'ı azaltıcı etkisinin olmadığı kanısına varıldı.

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Cite This Article

DOĞAN, Z., BUT, A. K., ERDEM, T. B., ERSOY, M. Ö., DURMUŞ, M. (2022). The effects of dexmedetomidine on sevoflurane minimum alveolar concentrations. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 33 - Sayı: 1, 43–47. https://ajindex.com/articles/620105

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