SavedAdd your journal

Journals / Türk Anestezi ve Reanimasyon Dergisi / 2006 / Cilt: 34 - Sayı: 5

The discussion of methemoglobinemia caused by local anesthetics in four cases

Lokal anesteziklere bağlı gelişen methemoglobineminin dört olguda tartışılması

Feyhan Ökten
Gümgör Enver ÖZGENCİL
Menekşe HASDOĞAN
Özlem Selvi CAN
Gül SEZER
Perihan ERDOĞDU
Pages
327–332
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this report, four methemoglobinemia cases depended on local anesthetic toxicity, occurred in Orthopedic surgery theater in the last 10 years are reported and these cases are discussed by looking over the published data from the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Although methemoglobinemia is a rare clinical condition, it causes hazardous effects unless it is treated in a proper ways in early period.
📊
Key Findings & Data:Methemoglobin results from oxidation of ferrous iron (Fe2+) of the hemoglobin molecule to ferric iron (Fe3+).
💡
Conclusion & Impact:In this report, four methemoglobinemia cases depended on local anesthetic toxicity, occurred in Orthopedic surgery theater in the last 10 years are reported and these cases are discussed by looking over the published data from the literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Although methemoglobinemia is a rare clinical condition, it causes hazardous effects unless it is treated in a proper ways in early period. Methemoglobin results from oxidation of ferrous iron (Fe2+) of the hemoglobin molecule to ferric iron (Fe3+). It is not difficult to diagnose methemoglobinemia in clinically suspicious conditions. In this report, four methemoglobinemia cases depended on local anesthetic toxicity, occurred in Orthopedic surgery theater in the last 10 years are reported and these cases are discussed by looking over the published data from the literature.

Özet

Methemoglobinemi ender görülen bir klinik durum olmasına rağmen, zamanında ve uygun tedavi edilmediği taktirde tehlikeli boyutlara ulaşabilir. Methemoglobin, hemoglobin molekülündeki demirin ferröz formdan (Fe2+), ferrik forma (Fe3+) oksidasyonu sonucu oluşur. Klinik olarak şüphelenildiğinde, methemoglobinemi tanısını koymak zor değildir. Bu yazıda, son 10 yıl içinde ortopedi ameliyathanesinde meydana gelen, lokal anesteziklere bağlı dört methemoglobinemi vakası bildirilmiş ve vakalar bu konuda yayınlanmış literatür bilgileri gözden geçirilerek tartışılmıştır.

🔖

Cite This Article

Ökten, F., ÖZGENCİL, G. E., HASDOĞAN, M., CAN, Ö. S., SEZER, G., ERDOĞDU, P. (2022). The discussion of methemoglobinemia caused by local anesthetics in four cases. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 34 - Sayı: 5, 327–332. https://ajindex.com/articles/620095

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Price D. Methemoglobinemia. In: Goldfrank LR, Flomenbaum N, Levin N, et al. (eds). Goldfrank's Toxicologic Emergencies. 6 th ed. Old Toppan NJ: Appleton Lange 1998; 1507-1523
  2. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: Etiology, Pharmacology, and Clinical Management. Ann Emerg Med 1999; 34(5):646-656
  3. Lee DC, Tuyl VA. Methemoglobinemia. eMedicine J (online) 2005: Available at: http//www. eMedicine. com/emerg/topic313htm
  4. Bayard M, Farrow J, Tudiver F. Acute methemoglobinemia after endoscopy. J Am Board Fam Pract 2004; 17(3):227-229
  5. Margulies DR, Manookian CM. Methemoglobinemia as a cause öf respiratory failure. J Trauma 2002; 52:796-797
  6. Schroeder TH, Dieterich HJ, Muhibauer B. Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. Acta Anaesthesiol Scand 1999; 43(4):480-482
  7. Kortgen A, Janneck U, Vetsch A, Bauer M. Methemoglobinemia due to prilocaine after plexus anesthesia. Reduction by prophylactic administration of ascorbic acid? Anaesthesist 2003; 52(ll):1020-1026
  8. Bardoczky GI, Wathieu M, D'Hollander A. Prilocaine- induced methemoglobinemia evidenced by pulse oximetry. Acta Anaesthesiol Scand 1990; 34(2): 162-164
  9. Bryne FM, Mitchell RM, Gerke H, Goller S, Stiffler HL, Golioto M, et al. The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia. J Clin Gastroenterol 2004; 38(3):225-229
  10. Emran MA, Martin TR, Villalba M, Blasco TA, Sulkowski RJ, Shah M. Methemoglobinemia in a trauma patient. J Trauma 2004; 57:642-644
  11. Slaughter MS, Gordon PJ, Roberts JC, Pappas PS. An unusual case of hypoxia from benzocaine-induced methemoglobinemia. Ann Thorac Surg 1999; 67:1776-1778
  12. Singh RK, Kambe JC, Andrews LK, Russell JC. Benzocaine-induced methemoglobinemia accompanying adult respiratory distress syndrome and sepsis syndrome: case report. J Trauma 2001; 50:1153-1157
  13. Nguyen ST, Cabroles Re, Bashour Ca, et al. Benzocaine induced methemoglobinemia. Anesth Analg 2000; 90:369-371
  14. Vidyarthi V, Manda R, Ahmed A, Khosia S, Lubell D. Severe methemoglobinemia after transesophageal echo-, cardiography. Am J Ther 2003; 10:225-227
  15. Moore TJ, Walsh CS, Cohen MR. Reported adverse event cases of methemoglobinemia associated with benzocaine products. Arch Intern Med 2004; 164(11):1192-1196
  16. Hjelt K, Lund JT, Scherling B, et al. Methomoglobinemia among neonates in a neonatal intensive care