Effects of dexmedetomidine infusion on hemodynamic responses in craniotomies

Same drugs were administered to the both groups for premedication, induction and maintenance.Results: Heart rate, systolic and diastolic arterial pressures reduced at 5th minute of infusion compared to initial values in dexmedetomidine group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The effectiveness of dexmedetomidine infusion on preventing hemodynamic response to intubation, skull pins and surgical incision in craniotomy operations was evaluated.Materials and Methods: Fourty ASA I-II patients undergoing craniotomy because of supratentorial tumors were randomised into: study group (n=20) received 1 µg kg h-1 dexmedetomidine, and control group (n=20) received 0,9 % NaCl infusion, 5 min. prior to induction.

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Key Findings & Data:After intubation was performed at 10th minute, infusion rates were reduced to 50 % in both groups.

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Conclusion & Impact:Same drugs were administered to the both groups for premedication, induction and maintenance.Results: Heart rate, systolic and diastolic arterial pressures reduced at 5th minute of infusion compared to initial values in dexmedetomidine group (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Aim: The effectiveness of dexmedetomidine infusion on preventing hemodynamic response to intubation, skull pins and surgical incision in craniotomy operations was evaluated.Materials and Methods: Fourty ASA I-II patients undergoing craniotomy because of supratentorial tumors were randomised into: study group (n=20) received 1 µg kg h-1 dexmedetomidine, and control group (n=20) received 0,9 % NaCl infusion, 5 min. prior to induction. After intubation was performed at 10th minute, infusion rates were reduced to 50 % in both groups. Control group received 1 µg kg-1 fentanyl; dexmedetomidine group received 0,9 % NaCl intravenously before skull pins. Same drugs were administered to the both groups for premedication, induction and maintenance.Results: Heart rate, systolic and diastolic arterial pressures reduced at 5th minute of infusion compared to initial values in dexmedetomidine group (p

Özet

Amaç: Çalışmamızda, kraniyotomi operasyonlarında indüksiyon öncesinde başlayarak cerrahi insizyon öncesine kadar sürdürülen deksmedetomidin infüzyonunun, laringoskopi, çivili başlık ve cerrahi insizyona hemodinamik yanıtı önlemedeki etkinliği araştırılmıştır.Gereç ve Yöntem: Supratentoryal kitle nedeniyle opere edilecek ASA I-II grubundan 40 olgu, indüksiyondan 5 dk. önce rasgele iki gruba ayrılarak çalışma grubuna (n=20) 1 µg kg sa-1 deksmedetomidin, kontrol grubuna (n=20) % 0.9 NaCl infüzyonu başlatıldı. On dakika sonra entübasyon gerçekleştirildi ve iki grupta da infüzyon hızları % 50 azaltıldı. Kontrol grubunda çivili başlıktan 5 dk. önce 1 µg kg-1 fentanil, deksmedetomidin grubunda 2 mL % 0.9 NaCl iv verildi. İki grupta premedikasyon, indüksiyon ve idame ilaçları aynıydı.Bulgular: Deksmedetomidin grubunda infüzyonun 5. dakikasında kalp hızı ile sistolik ve diyastolik arter basınçları, öncesine göre düşük bulundu (p

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Cite This Article

KAYA, G., ÇOLAK, A., KARAÇAYIR, Y., ALAGÖL, A., TURAN, F. N., PAMUKÇU, Z. (2022). Effects of dexmedetomidine infusion on hemodynamic responses in craniotomies. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 34 - Sayı: 4, 236–240. https://ajindex.com/articles/620081

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