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Journals / Türk Anestezi ve Reanimasyon Dergisi / 2006 / Cilt: 34 - Sayı: 2

Effects of fentanil, alfentanil and remifentanil onto hemodynamic responses to laryngoscopy and endotracheal intubation

Laringoskopi ve endotrakeal entübasyona karşı gelişen hemodinamik yanıtın önlenmesinde fentanil, alfentanil ve remifentanilin etkinliği

Gürkan TÜRKER
Alp GURBET
Berin ÖZCAN
İlhan C. GÖKÇE
Hülya BİLGİN
Pages
111–117
Publication Date
2022-11-05
DOI
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T test used for group comparison, Mann-Whitney U, Wilcoxon Signed Ranks and Kruskal-Wallis tests were used for statistical analyses. p value is

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Objective & Hypothesis:Aim: In this study, we aimed to compare fentanyl, alfentanil and a new opioid agent remifentanil with respect to reflex hemodynamic responses to laryngoscopy and endotracheal intubation in general anesthesia practice.Material and Methods: 90 patients were included in the study and were randomly divided into three equal groups.
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Key Findings & Data:General anesthesia induced with thiopenthal sodium 5-7 mg kg-1.
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Conclusion & Impact:T test used for group comparison, Mann-Whitney U, Wilcoxon Signed Ranks and Kruskal-Wallis tests were used for statistical analyses. p value is
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: In this study, we aimed to compare fentanyl, alfentanil and a new opioid agent remifentanil with respect to reflex hemodynamic responses to laryngoscopy and endotracheal intubation in general anesthesia practice.Material and Methods: 90 patients were included in the study and were randomly divided into three equal groups. General anesthesia induced with thiopenthal sodium 5-7 mg kg-1. Patients were received 15 µg kg-1 alfentanil (Group A), 2 µg kg-1 fentanyl (Group F) and 0.5 µg kg-1 remifentanil (Group R) boluses, respectively. Two minutes after vecuronium bromide 0.1 mg kg-1 injection for muscle relaxation, patients were intubated with direct laryngoscopy. Heart rates, systolic and diastolic arterial pressures, mean arterial pressures were recorded before and after induction, and after laryngoscopy and intubation for 6 times. T test used for group comparison, Mann-Whitney U, Wilcoxon Signed Ranks and Kruskal-Wallis tests were used for statistical analyses. p value is

Özet

Giriş: Genel anestezi uygulamalarında, endotrakeal entübasyona karşı gelişebilecek hemodinamik yanıtın baskılanmasında fentanil ve alfentanil ile yeni bir opioid ajan olan remifentanil'i karşılaştırmayı amaçladık.Gereç ve Yöntem: Çalışmaya 90 olgu alındı. Genel anestezi indüksiyonu 5-7 mg kg-1 tiyopental sodyum ile sağlandı. Birinci gruptaki (A) olgulara 15 µg kg-1 alfentanil; ikinci gruptaki (F) olgulara 2 µg kg-1 fentanil ve üçüncü gruptaki (R) olgulara 0.5 µg kg-1 remifentanil bolus tarzında uygulandı. Kas gevşemesi için 0.1 mg kg-1 vekuronyum bromid uygulamasından iki dakika sonra olgular direkt laringoskopi ile entübe edildiler. Çalışma süresince kalp atım hızı (KAH), sistolik arter basıncı (SAB), diyastolik arter basıncı (DAB), ortalama arter basıncı (OAB) ölçüm ve takibi 6 ayrı dönemde gerçekleştirildi. İstatistik değerlendirmelerinde T testi, Mann Whitney U, Wilcoxon Signed Rank ve Kruskal-Wallis testleri kullanıldı. p

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Cite This Article

TÜRKER, G., GURBET, A., ÖZCAN, B., GÖKÇE, İ. C., BİLGİN, H. (2022). Effects of fentanil, alfentanil and remifentanil onto hemodynamic responses to laryngoscopy and endotracheal intubation. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 34 - Sayı: 2, 111–117. https://ajindex.com/articles/620072

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