AI Summary & Key Takeaways
AI InsightThere was no statistically significant difference between groups (p>0.05).We decided cisatracurium provides good intubation conditions, there is no difference between age for Tmax, T25, T75 and recovery index, and using sevoflurane or desflurane has no influence on these parameters.
📌 3 Key Takeaways
Abstract
In this study we compared the entubation quality and duration to maximum blockage, and after intubation the neuromuscular effects of cisatracurium with sevoflurane or desflurane.Eighty patients with ASA I-II physical status in two groups of forty young (25-49 years) and forty elderly (65-86 years) were included. Motor function of the thumb was monitorized by the stimulation of ulnar nerve. Anesthesia induction was made with fentanyl 1 µg kg-1, and propofol 2 mg kg-1. The neuromuscular blockage was measured by accelomyograph (Paragraph, USA). After control value was obtained cisatracurium 0.1 mg kg-1 was applied. Time to 100 % neuromuscular blockage was recorded as Tmax thenafter intubation was performed. The quality was evaluated as perfect, good and bad. The patients were subgrouped according to the inhalation anesthetics (sevoflurane or desflurane) and T25 (duration of clinical effect, min.), T75 (time to need supplementary dosage, min.), T25-T75 (recovery index, min.) were studied by TOF stimulation. Students t, Ki square, repeated measures of ANOVA and posthoc Tukey-kramer tests were used for statistical analyses.The intubation quality was evaluated as 60 % perfect, 40 % good in youngs, and 70 % perfect, 30 % good in elderly. Tmax was found 200 sec.-204 sec. respectively. T25, T75 and recovery index was found 31.9, 38.5, 6.6 min. in young-sevoflurane group, 32.6, 38.9, 6.3 min. in young-desflurane group, 33.4, 40.4, 6.9 min. in elderly sevoflurane group, 36.2, 43.0, 6.8 min., respectively. There was no statistically significant difference between groups (p>0.05).We decided cisatracurium provides good intubation conditions, there is no difference between age for Tmax, T25, T75 and recovery index, and using sevoflurane or desflurane has no influence on these parameters.
Özet
Bu çalışmada, sisatrakuryumun entübasyon kalitesi ve maksimum bloğa geçiş süresi, entübasyonun ardından sevofluran veya desfluran kullanımına göre nöromüsküler etkileri genç ve yaşlılarda karşılaştırıldı.Çalışmamız 40 genç (25-49 yaş) ve 40 yaşlı (65-86 yaş) olmak üzere 80 hastaya (ASA I- II) uygulandı. Ulnar sinir uyarılarak başparmak motor fonksiyonu monitörize edildi. İndüksiyon fentanil 1 µg kg-1, propofol 2 mg kg-1 ile yapıldı. Blok akselomiyografi yöntemiyle (Paragraph, USA) ölçüldü. Tekli uyarıyla kontrol değeri elde edildi ve 0.1 mg kg-1 sisatrakuryum verildi. Nöromüsküler bloğun % 100'e ulaşma süresi (Tmax, sn.) olarak kaydedilip, ardından entübasyon gerçekleştirildi. Kalitesi mükemmel, iyi, kötü olarak değerlendirildi. Hastalar sevofluran veya desfluran kullanımına göre alt gruplara ayrılarak TOF uyarısı ile T25 (klinik etki süresi, dk.), T75 (ek doz gereksinim zamanı, dk.), T25-75 (iyileşme indeksi, dk.) araştırıldı. İstatistiksel değerlendirmede Student's t, Ki kare, repeated measures ANOVA, Tukey-kramer testleri kullanıldı. P0.05'di.Bu çalışmamızla sisatrakuryumun mükemmel- iyi koşullarda entübasyon kalitesi sağladığı, Tmax, T25, T75, iyileşme indeksi açısından genç ve yaşlıda fark göstermediği, sevofluran veya desfluran kullanımının bu parametreleri etkilemediği kanısına vardık.