Journals / Türk Anestezi ve Reanimasyon Dergisi / 2010 / Cilt: 38 - Sayı: 1

The effects of esmolol ınfusion in craniotomies

Kraniyotomilerde esmolol infüzyonunun etkileri

Pages
35–44
Publication Date
2022-11-05
DOI
—
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Conclusion: It was concluded that esmolol infusion is a safe and useful method in patients undergoing craniotomies.regarding maintenance of hemodynamic stability, reduction of total fentanyl dose used and achievement of an earlier postoperative recovery.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The effects of esmolol infusion on perioperative haemodynamic parameters, total amounts of fentanyl used and recovery were investigated in patients who experienced craniotomies.
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Key Findings & Data:In the esmolol group, patients received esmolol at a loading dose of 500 μg/kg, and then as an infusion at a rate of 100 μg/kg/min.
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Conclusion & Impact:Conclusion: It was concluded that esmolol infusion is a safe and useful method in patients undergoing craniotomies.regarding maintenance of hemodynamic stability, reduction of total fentanyl dose used and achievement of an earlier postoperative recovery.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The effects of esmolol infusion on perioperative haemodynamic parameters, total amounts of fentanyl used and recovery were investigated in patients who experienced craniotomies. Material and Method: Forty cases were randomized into two groups as esmolol and control groups. In the esmolol group, patients received esmolol at a loading dose of 500 μg/kg, and then as an infusion at a rate of 100 μg/kg/min. Five minutes after the extubation, esmolol infusion was stopped. During the operation fentanyl infusion were administered at doses of 0.015-0.05 μg/kg/min so as to maintain targeted mean arterial pressure at 90-110 mmHg Mean arterial pressures and heart rates, total amounts of fentanyl used, the number of changes in fentanyl infusion rates, and time to reach an Aldrete recovery score of 9 were recorded. Results: In the esmolol group, heart rates and mean arterial pressures were maintained better during the perioperative period. In the esmolol group total amount of fentanyl used and the number of changes in fentanyl infusion rates decreased significantly, and the time to reach an Aldrete recovery score of 9 was significantly more prolonged relative to the control group. Conclusion: It was concluded that esmolol infusion is a safe and useful method in patients undergoing craniotomies.regarding maintenance of hemodynamic stability, reduction of total fentanyl dose used and achievement of an earlier postoperative recovery.

Özet

Amaç: Kraniyotomi uygulanan olgularda esmolol infüzyonunun; perioperatif hemodinamik değişikliklerin kontrolüne, tüketilen fentanil miktarına ve derlenme üzerine etkileri araştırıldı. Gereç ve Yöntem: Kırk olgu rasgele iki gruba (esmolol grubu, kontrol grubu) ayrıldı. Esmolol grubunda, esmolol 500 μg kg-1 yükleme dozundan sonra 100 μg kg-1 dk-1 infüzyon başlandı, ekstübasyondan 5 dk. sonra infüzyon durduruldu. Operasyon süresince olguların hedef ortalama arter basıncı 90-110 mmHg olacak şekilde fentanil 0,015-0,05 μg kg-1 dk-1 infüzyonu uygulandı. Ortalama arter basıncı ve kalp atım hızı değerleri, toplam fentanil tüketimi, fentanil infüzyonunda yapılan değişikliklerin sayısı, ekstübasyon sonrası Aldrete derlenme skorunun 9 olma süresi kaydedildi. Bulgular: Esmolol uygulanan olgularda, perioperatif dönemde kalp atım hızı ve ortalama arter basıncının daha iyi kontrol edildiği gözlendi. Esmolol grubunda tüketilen toplam fentanil miktarı ve fentanil infüzyon hızında yapılan değişikliklerin sayısı ile ekstübasyon sonrası Aldrete derlenme skorunun 9 olma süresi kontrol grubuna göre anlamlı derecede düşüktü. Sonuç: Kraniyotomi uygulanan hastalarda esmolol infüzyonunun hemodinamik stabilitenin korunmasında, fentanil tüketiminin azaltılmasında ve buna bağlı olarak erken postoperatif derlenmenin sağlanmasında yararlı ve güvenli bir yöntem olduğu kanısına varıldı.

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Cite This Article

ÇELİK, M., ELMACI, İ., KOLTKA, E. N., SAĞIROĞLU, A. E., BUDAKÇI, T. (2022). The effects of esmolol ınfusion in craniotomies. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 38 - Sayı: 1, 35–44. https://ajindex.com/articles/619862

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