Journals / Türk Anestezi ve Reanimasyon Dergisi / 2012 / Cilt: 40 - Sayı: 3

Theophylline intoxication during anesthesia: A case report and literature review

Anestezi sırasında teofilin intoksikasyonu: Bir olgu sunumu ve literatür gözden geçirilmesi

Pages
174–178
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The treatment was symptomatic and patient was transported to the pediatic surgery department and sent home after 48 hours without any problem.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Theophylline is an effective dimethylxantine bronchodilator.
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Key Findings & Data:We described a high dose theophylline injection during the induction of the anesthesia in a 2 year-old 14 kg-male patient scheduled for orchiopexy with the indication of undescended testis.
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Conclusion & Impact:The treatment was symptomatic and patient was transported to the pediatic surgery department and sent home after 48 hours without any problem.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Theophylline is an effective dimethylxantine bronchodilator. Serious toxicity might develop because of its narrow therapeutic index. We described a high dose theophylline injection during the induction of the anesthesia in a 2 year-old 14 kg-male patient scheduled for orchiopexy with the indication of undescended testis. Ten milliliter undiluted theophylline (24 mg/mL) had been administered instead of diluted rocuronium (1 mg/mL) during the induction of anesthesia. The patient had tachycardia and temporary hypotension, and treated with lidocaine injection. Remifentanil was infused (1 mcg/kg/min) for analgesia. Blood theophylline level was 30. 7 mcg/mL after 45 minutes of administration. The surgery was completed in two hours and the patient was referred to the intensive care unit for observation. Then blood theophylline level was 27.4 mcg/mL and his cardiac, metabolic and neurological status was uneventful except mild hypokalemia, hyperglycemia and tachycardia in the ICU. The treatment was symptomatic and patient was transported to the pediatic surgery department and sent home after 48 hours without any problem.

Özet

Teofilin bronkodilatatör tedavide etkili bir dimetilksantin türevidir. Terapötik sınırının dar olması nedeniyle ciddi toksisiteye neden olabilir. Bu olgu sunumunda anestezi indüksiyonu sırasında yüksek doz teofilin injeksiyonu yapılan bir olgu sunulacaktır. İnmemiş testis nedeniyle orşiopeksi operasyonu planlanan 2 yaşında ve 14 kg olan hastaya anestezi indüksiyonu sırasında dilüe rokurunium (1 mg/mL) yerine 10 mL 24 mg/cc konsantrasyonda teofilin injeksiyonu yapıldı. Hastanın anestezi sırasında oluşan taşikardi ve hipotansiyonu için lidokain uygulandı ardından analjezi için Remifentanil infüzyonu 1 mcg/kg/dk. ile başlandı. Teofilin düzeyi injeksiyondan 45 dk. sonra kanda 30.7 mcg/mL olarak ölçüldü. Cerrahi iki saat sonra sorunsuz olarak tamamlandı ve hasta gözlem amacıyla yoğun bakım ünitesine gönderildi. Teofilin düzeyi yoğun bakım ünitesinde 27.4 mcg/mL bulundu ve hastada kalp, metabolizma ve nöroloji açısından, orta derecede hipokalemi, hiperglisemi ve taşikardisi dışında sorunu saptanmadı. Hasta yoğun bakım ünitesinde uygulanan semptomatik ve destek tedavisinin ardından 24 saat sonra çocuk cerrahisi servisine ve 48 saat sonra da evine gönderildi.

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Cite This Article

ARKAN, H., KAYA, G., TÜTÜNCÜ, A. Ç., APAYDIN, H., IŞIKÇI, Y., ALTINDAŞ, F. (2022). Theophylline intoxication during anesthesia: A case report and literature review. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 40 - Sayı: 3, 174–178. https://ajindex.com/articles/619812

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