AI Summary & Key Takeaways
AI InsightWe conclude that strains resistant to Streptomycin are susceptible to amikacin.
📌 3 Key Takeaways
Abstract
Consideration of cross resistance is important for selecting the acceptable drug for treatment of apparent or proven multidrug resistant tuberculosis. When resistance to Streptomycin is proved or highly suspected, one of the other aminoglycosides can be used. We aimed to determine the cross resistance in Mycobacterium tuberculosis strain between Streptomycin, kanamycin, amikacin. 100 culture positive sputum specimens of lung tuberculosis patients were involved in this study. We found cross resistance between Streptomycin and kanamycin (p< 0.01). There was also cross resistance between kanamycin and amikacin (p< 0.001). Cross resistance was not obsemed between Streptomycin and amikacin (p< 0.05). We conclude that strains resistant to Streptomycin are susceptible to amikacin.
Özet
Çok ilaca dirençli tüberkülöz tedavisindeki uygun ilaç seçiminde çapraz direncin düşünülmesi önemlidir.Streptomisin direnci varsa veya yüksek olasılıkla dirençten şüphe ediliyorsa diğer bir aminpglikozid kullanılabilir.Çalışmamızda, Mycobacterium tuberculosis' e karşı streptomisin, kanamisin ve amikasin arasında çapraz direnci araştırmayı amaçladık.Çalışmaya, akciğer tüberkülozlu hastalardan elde edilen 100 kültür pozitif balgam örneği alındı.Streptomisin ve kanamisin arasında çapraz direnç saptadık (p