Journals / Turkish Journal of Pharmaceutical Sciences / 2021 / Cilt: 18 - Sayı: 3

Mechanistic Biomarkers in Toxicology

Toksikolojide Mekanistik Biyobelirteçler

Pages
136–141
Publication Date
2022-11-02
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, the present study focused on the possible mechanistic biomarkers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Biomarkers are important parameters that are reliable, applicable, reproducible, and generally inexpensive.
📊
Key Findings & Data:All biomarkers have a significant role in human health, especially mechanistic biomarkers, which are the most important for the prevention of toxic effects and diseases.
💡
Conclusion & Impact:Therefore, the present study focused on the possible mechanistic biomarkers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Biomarkers are important parameters that are reliable, applicable, reproducible, and generally inexpensive. All biomarkers have a significant role in human health, especially mechanistic biomarkers, which are the most important for the prevention of toxic effects and diseases. They demonstrate the possibility of diagnosis, prognosis, recurrence, and spread of disease. Furthermore, they show the exposure levels to numerous chemical, biological, and physical agents. To date, the development and application of biomarkers require the knowledge of mechanisms underlying their production. Therefore, the present study focused on the possible mechanistic biomarkers.

Özet

Biyobelirteçler önemli, güvenilir, uygulanabilir, tekrarlanabilir ve genelikle maliyeti uygun parametrelerdir. Biyobelirteçlerin insan sağlığı açısından önemli rolü olmakla birlikte özellikle mekanistik biyobelirteçlerin toksik etki ve hastalıklardan korunmada önemi büyüktür. Biyobelirteçler hastalıkların tanısını, gidişatını, tekrarlama ve yayılma olasılığını, tedavinin etkinliğini gösterebilir. İlave olarak birçok kimyasal, biyolojik ve fiziksel ajanlara maruz kalma düzeyini gösterir. Bugün biyobelirteç geliştirilmesi ve uygulanması, bunların oluşumunun altında yatan mekanizma bilgilerini gerektirir. Bu nedenle bu yazıda olası mekanistik biyobelirteçler üzerinde yoğunlaşılmıştır.

🔖

Cite This Article

SANAJOU, S., ŞAHİN, G. (2022). Mechanistic Biomarkers in Toxicology. Turkish Journal of Pharmaceutical Sciences, Cilt: 18 - Sayı: 3, 136–141. https://ajindex.com/articles/613638

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89-95. Gupta RC. Biomarkers in Toxicology. Kentucky: Elsevier, Academic Press; 2014. Mayeux R. Biomarkers: potential uses and limitations. NeuroRx. 2004;1:182-188.
  2. Aitio A, Anderson D, Blain P, et al. Biomarkers and risk assessment: Concepts and principles. Environmental Health Criteria 155. 1993;3-82. Available from: https://wedocs.unep. org/bitstream/handle/20.500.11822/29540/EHC155BRA. pdf?sequence=1&isAllowed=y Nordberg GF. Biomarkers of exposure, effects and susceptibility in humans and their application in studies of interactions among metals in China. Toxicol Lett. 2010;192:45-49.
  3. Robinson WH, Lindstrom TM, Cheung RK, Sokolove J. Mechanistic biomarkers for clinical decision making in rheumatic diseases. Nat Rev Rheumatol. 2013;9:267-276.
  4. McGill MR, Woolbright BL, Weemhoff JL, Jaeschke H. Mechanistic Biomarkers in Liver Diseases. 2017:623-635. Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem. 1995;41(12 Pt 2):1819-1828. Sies H. Oxidative Stress: Introductory Remarks. Pergamon press inc.; 1985.
  5. Giustarini D, Dalle-Donne I, Tsikas D, Rossi R. Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers. Crit Rev Clin Lab Sci. 2009;46:241-281.
  6. Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem. 2006;52:601-623.
  7. Marrocco I, Altieri F, Peluso I. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxid Med Cell Longev. 2017;2017:6501046. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017. doi:10.1155/2017/8416763. Thomas C, Mackey MM, Diaz AA, Cox DP. Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation. Redox Rep. 2009;14:102-108.
  8. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5:9-19. Peña-Bautista C, Baquero M, Vento M, Cháfer-Pericás C. Free radicals in Alzheimer’s disease: Lipid peroxidation biomarkers. Clin Chim Acta. 2019 Apr;491:85-90.
  9. Yavuzer H, Yavuzer S, Cengiz M, Erman H, Doventas A, Balci H, Erdincler