SavedAdd your journal

Journals / Turkish Journal of Obstetrics and Gynecology / 2021 / Cilt: 18 - Sayı: 4

Increased sulfiredoxin-1 levels as compensatory mechanism against reactive oxygen species in women with gestational diabetes mellitus

Gestasyonel diabetes mellituslu kadınlarda reaktif oksijen türlerine karşı telafi edici bir mekanizma olarak sülfiredoksin-1 düzeyleri artmaktadır

Uğur TURHAN
Burak TATAR
Pages
267–271
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Fasting plasma glucose, first and second-hour plasma glucose levels, fasting insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR), and Srx-1 levels were significantly different in patients with GDM than control (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aimed to investigate the correlation between serum Sulfiredoxin-1 (Srx-1) levels and gestational diabetes mellitus (GDM).
📊
Key Findings & Data:Materials and Methods: A total of 40 patients diagnosed with GDM according to the American Diabetes Association Criteria and 40 age matched and gestational age-matched healthy pregnant women as a control group were included in this cross-sectional study.
💡
Conclusion & Impact:Results: Fasting plasma glucose, first and second-hour plasma glucose levels, fasting insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR), and Srx-1 levels were significantly different in patients with GDM than control (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to investigate the correlation between serum Sulfiredoxin-1 (Srx-1) levels and gestational diabetes mellitus (GDM). Materials and Methods: A total of 40 patients diagnosed with GDM according to the American Diabetes Association Criteria and 40 age matched and gestational age-matched healthy pregnant women as a control group were included in this cross-sectional study. Serum Srx-1 levels and other demographic and laboratory variables were analyzed. Results: Fasting plasma glucose, first and second-hour plasma glucose levels, fasting insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR), and Srx-1 levels were significantly different in patients with GDM than control (p

Özet

Amaç: Bu çalışma serum Sülfiredoksin-1 (Srx-1) düzeyleri ile gestasyonel diabetes mellitus (GDM) arasında bir korelasyon olup olmadığını araştırmayı amaçlamaktadır. Gereç ve Yöntemler: Amerikan Diyabet Derneği Kriterleri’ne göre GDM tanısı alan toplam 40 hasta ve kontrol grubu olarak yaş ve gebelik haftası eşleşen 40 sağlıklı gebe bu kesitsel çalışmaya dahil edildi. Serum Srx-1 düzeyleri ile diğer demografik ve laboratuvar değişkenleri analiz edildi. Bulgular: Açlık plazma glukoz, birinci ve ikinci saat plazma glikoz düzeyleri, açlık insülin düzeyleri, insülin direncinin homeostaz modeli değerlendirmesi (HOMA-IR) ve Srx-1 düzeyleri GDM hastalarında kontrol grubundan anlamlı olarak farklıydı (p

🔖

Cite This Article

TURHAN, U., TATAR, B. (2022). Increased sulfiredoxin-1 levels as compensatory mechanism against reactive oxygen species in women with gestational diabetes mellitus. Turkish Journal of Obstetrics and Gynecology, Cilt: 18 - Sayı: 4, 267–271. https://ajindex.com/articles/612900

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. ACOG Practice Bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol 2018;131:e49-64. doi: 10.1097/ AOG.0000000000002501
  2. Yogev Y, Xenakis EM, Langer O. The association between preeclampsia and the severity of gestational diabetes: the impact of glycemic control. Am J Obstet Gynecol 2004;191:1655-60
  3. Ehrenberg HM, Durnwald CP, Catalano P, Mercer BM. The influence of obesity and diabetes on the risk of cesarean delivery. Am J Obstet Gynecol 2004;191:969-74
  4. Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 2002;25:1862-8
  5. Rhee SG, Chae HZ, Kim K. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med 2005;38:1543-52
  6. Hofmann B, Hecht HJ, Flohe L. Peroxiredoxins. Biol Chem 2002;383:347-64
  7. Rhee SG, Kang SW, Chang TS, Jeong W, Kim K. Peroxiredoxin, a novel family of peroxidases. IUBMB Life 2001;52:35-41
  8. Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, et al. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 2003;424:561- 5
  9. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 2007;43:477-503
  10. Rhee SG, Kang SW, Jeong W, Chang TS, Yang KS, Woo HA. Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr Opin Cell Biol 2005;17:183-9
  11. O’Neill JS, van Ooijen G, Dixon LE, Troein C, Corellou F, Bouget FY, et al. Circadian rhythms persist without transcription in a eukaryote. Nature 2011;469:554-8
  12. Bass J, Takahashi JS. Circadian rhythms: Redox redux. Nature 2011;469:476-8
  13. Sun Y, Hegamyer G, Colburn NH. Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res 1994;54:1139- 44
  14. Jeong W, Park SJ, Chang TS, Lee DY, Rhee SG. Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin. J Biol Chem 2006;281:14400-7
  15. Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne I. S-glutathionylation: from redox regulation of protein functions to human diseases. J Cell Mol Med 2004;8:201-12
  16. Findlay VJ, Tapiero H, Townsend DM. Sulfiredoxin: a potential therapeutic agent? Biomed Pha