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Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2002 / Cilt: 16 - Sayı: 1

The relationship between Heat-shock protein 70, 90 expression and myometrial invasion

Endometrioid adenokarsinomlarda Heat-shock protein 70, 90 ve tenasin ekspresyonunun myometrial invazyon derinliği ile ilişkisi

Meral KOYUNCUOĞLU
Gözde GÖRÜCÜ
Uğur SAYGILI
Bilkay İlknur GÖRKEM
Emek ÖZEN
Turhan USLU
Oktay ERTEN
Pages
9–21
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The expression of HSP 70 in endometrioid adenocarcinoma may be considered as a poor prognostic factor.

📌 3 Key Takeaways

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Objective & Hypothesis:Object: Our aim is to investigate to immunohistochemical expression of HSP 70,90 and tenascin in endometrioid adenocarcinoma and to search for the relationship between HSP 70,90 and tenascin expression and histological grade, stage, age and myometrial invasion.
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Key Findings & Data:Material and method: We analyzed the expression of HSP 70,90 and tenascin by immunohistochemistry in 78 -cases with endometrioid adenocarcinoma and the relationship between HSP 70,90 and tenascin expression and histological grade, stage, age and myometrial invasion.
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Conclusion & Impact:Conclusion: The expression of HSP 70 in endometrioid adenocarcinoma may be considered as a poor prognostic factor.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Seyir · Neoplazm evrelendirilmesi · Tenaskin

Abstract

Object: Our aim is to investigate to immunohistochemical expression of HSP 70,90 and tenascin in endometrioid adenocarcinoma and to search for the relationship between HSP 70,90 and tenascin expression and histological grade, stage, age and myometrial invasion. Material and method: We analyzed the expression of HSP 70,90 and tenascin by immunohistochemistry in 78 -cases with endometrioid adenocarcinoma and the relationship between HSP 70,90 and tenascin expression and histological grade, stage, age and myometrial invasion. Results: The expression of HSP 70 was observed in 89.7% (70 cases). There was no relationship between HSP70 expression and histological grade, stage and age. But we found positive relationship between HSP 70 expression and myometrial invasion (p<0.05). The expression of HSP90 and tenascin C were observed in 60.5% (48 cases), 34.6% (27 cases) respectively. There was no relationship between HSP90 and tenascin expression and histological grade, stage and myometrial invasion. Conclusion: The expression of HSP 70 in endometrioid adenocarcinoma may be considered as a poor prognostic factor.

Özet

Amaç: Endometrial kanserli olgularda HSP70, 90 ve tenasinin immunohistokimyasal ekspresyonunu incelemek ve HSP70, 90 ve tenasin ekspresyonu ile histolojik derece, evre, yaş ve myometrial İnvazyon ile ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmada 78 endometrial kanserli olguda HSP70, 90 ve tenasinin ekspresyonu immuııohistokimyasal yöntemle incelendi ve HSP70, 90 ve tenasin ekspresyonu ile histolojik derece, evre, yaş ve myometrial İnvazyon ile ilişkisi araştırıldı. Bulgular: HSP 70 ekspresyonu olguların %89.7'sinde (70 olgu) görüldü. HSP70 ekspresyonu ile histolojik derece, evre ve yaş arasında ilişki yoktu. Ancak myometrial İnvazyon derinliği ile ilişki saptandı (p<0.05). HSP90 ekspresyonu olguların %60.5 inde (48 olgu), tenasin ekspresyonu ise %34.6 olguda (27 olgu) görüldü. HSP 90 ve tenasin ekspresyonu ile histolojik derece, evre, yaş ve myometrial İnvazyon arasında ilişki görülmedi. Tenaskinin stromal ekspresyonu, histolojik derecesi yüksek olan olgularda yoğun olarak görüldü. Sonuç: Endometrial kanserlerde HSP 70 ekspresyonu, kötü prognostik faktör olarak değerlendirilebilir.

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Cite This Article

KOYUNCUOĞLU, M., GÖRÜCÜ, G., SAYGILI, U., GÖRKEM, B. İ., ÖZEN, E., USLU, T., ERTEN, O. (2002). The relationship between Heat-shock protein 70, 90 expression and myometrial invasion. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 16 - Sayı: 1, 9–21. https://ajindex.com/articles/222395

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