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Journals / Turkish Journal of Pharmaceutical Sciences / 2018 / Cilt: 15 - Sayı: 3

The Effect of Sumatriptan in Ischemic Conditions in the Rat Heart

Sumatriptanın Sıçan Kalbinde İskemik Koşullardaki Etkisi

Meral TUNCER
Hande Özge ALTUNKAYNAK ÇAMCA
Müge TECDER ÜNAL
Pages
328–332
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters.Results: The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection.Materials and Methods: The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC.
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Key Findings & Data:The mean arterial blood pressure andheart rate were recorded to calculate PRP.
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Conclusion & Impact:Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters.Results: The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection.Materials and Methods: The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure andheart rate were recorded to calculate PRP. Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters.Results: The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p

Özet

Amaç: Bu çalışmanın amacı, SUM’un, IR’nin sıçanlarda neden olduğu kardiyak hasar ve IPC’nin oluşturduğu koruyuculuk üzerine etkisini incelemektir. Gereç ve Yöntemler: Sıçanlar rastgele olarak; IR, SUM-IR, IPC ve SUM-IPC gruplarına bölündü. Ortalama arteriyel kan basıncı ve kalp atım hızı, basınç hız ürününü (PRP) hesaplamak için kaydedildi. Aritmi parametrelerini değerlendirmek için standart EKG’ler kaydedildi. Bulgular: SUM-IPC grubundaki PRP değerleri, SUM-IR grubundakilerden reperfüzyon başlangıcında anlamlı olarak daha düşüktü (p

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Cite This Article

TUNCER, M., ÇAMCA, H. Ö. A., ÜNAL, M. T. (2022). The Effect of Sumatriptan in Ischemic Conditions in the Rat Heart. Turkish Journal of Pharmaceutical Sciences, Cilt: 15 - Sayı: 3, 328–332. https://ajindex.com/articles/612094

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References (12)

  1. Ramage AG, Villalón CM. 5-hydroxytryptamine and cardiovascular regulation. Trends Pharmacol Sci. 2008;29:472-481. Villalón CM, De Vries P, Saxena PR. Serotonin receptors as cardiovascular targets. Drug Discovery Today. 1997;2:294-300. Weiss O. Ueber die Wirkungen von Blutserum-Injectionen ins Blut. Archiv für die Gesamte Physiologie des Menschen und der Thiere. 1896;65:215-230.
  2. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994;46:157-203.
  3. Duquesnoy C, Mamet JP, Sumner D, Fuseau E. Comparative clinical pharmacokinetics of single doses of sumatriptan following subcutaneous, oral, rectal and intranasal administration. Eur J Pharm Sci. 1998;6:99-104. Villalón CM, Centurión D. Cardiovascular responses produced by 5-hydroxytriptamine: a pharmacological update on the receptors/ mechanisms involved and therapeutic implications. Naunyn Schmiedebergs Arch Pharmacol. 2007;376:45-63.
  4. Mueller L, Gallagher RM, Ciervo CA. Vasospasm-induced myocardial infarction with sumatriptan. Headache. 1996;36:329-331.
  5. Laine K, Raasakka T, Mäntynen J, Saukko P. Fatal cardiac arrhythmia after oral sumatriptan. Headache. 1999;39:511-512.
  6. Lynch JJ Jr, Stump GL, Kane SA, Regan CP. The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis. J Cardiovasc Pharmacol. 2009;53:474-479.
  7. Kemp BK, Cocks TM. Effects of U46619 on contractions to 5-HT, sumatriptan and methysergide in canine coronary artery and saphenous vein in vitro. Br J Pharmacol. 1995;116:2183-2190.
  8. Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev. 2007;59:418-458.
  9. Krzeminski TF, Mitrega K, Porc M, Zorniak M, Ryszka F, Ostrowska Z, Kos-Kudła B. Differential action of two prolactin isoforms on ischemia and re-perfusion-induced arrhythmias in rats in vivo. J Endocrinol Invest. 2011;34:206-215.
  10. Baller D, Bretschneider HJ, Hellige G. A critical look at currently used indirect indices of myocardial oxygen consumption. Bas Res Cardiol. 1981;76:163-181.
  11. Fawaz G, Tutunji B. Ouabain-induced ventricular tachycardia and its effect on the performance and metabolism of the dog heart. Br J Pharmacol Chemother. 1959;14:355-357.
  12. Spokes RA, Middlefell VC. Simult