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Journals / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 6

Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats

Sebile Güler ÇEKİÇ
Edip Güvenç ÇEKİÇ
Dilek Ertoy BAYDAR
Meral TUNCER
Güray SOYDAN
Pages
1328–1339
Publication Date
2018-12-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, are consistent with the human findings of microvascular changes in preeclampsia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy.
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Key Findings & Data:Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11.
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Conclusion & Impact:Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, are consistent with the human findings of microvascular changes in preeclampsia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Suramin · preeclampsia · hypertension

Abstract

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries. Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Blood pressures of rats were observed daily. On the day 20, rats were executed. Protein levels in urine were measured and fetuses, placentas, and kidneys were weighted and evaluated. Thoracic aorta, renal, and uterine arteries were removed for functional studies. Results: Increased blood pressures and proteinuria were detected in suramin-given pregnant rats. Pathological examination of kidneys showed an acute tubular injury after suramin injection. Numbers and weights of fetuses and placentas were reduced in suramin-given pregnant rats. In functional studies, endothelial dysfunction occurred in uterine and renal arteries but not in the aorta. In this study, we showed that preeclampsia-like syndrome occurred in suramin-given rats. Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, are consistent with the human findings of microvascular changes in preeclampsia.

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Cite This Article

ÇEKİÇ, S. G., ÇEKİÇ, E. G., BAYDAR, D. E., TUNCER, M., SOYDAN, G. (2018). Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 6, 1328–1339. https://ajindex.com/articles/113883

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