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Journals / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 1

Effects of immunosuppressive drugs on oral mucosa in patients with Behçet?s disease: cytomorphological and cytopathological assessment

Necmettin AKDENİZ
Handan BİLEN
Hasan DOĞAN
Orhan ATEŞ
Nilnur EYERCİ
Sadullah KELEŞ
Eda DİYARBAKIR
Jale SELLİ
Adem KARA
Pages
145–151
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Changes in these parameters may indicate malignant transformation in the oral mucosa.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: The aim of this study was to investigate cytomorphological and cytopathological changes in oral exfoliated smears collected from immunosuppressed patients with Behçet s disease (BD) using stereological methods.
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Key Findings & Data:Results: The cytomorphological analysis revealed 3 types of mucosal cells, with numbers of particularly pink cells lower in the aphthous areas of the patients with BD compared to the healthy controls (P 0.05).
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Conclusion & Impact:Changes in these parameters may indicate malignant transformation in the oral mucosa.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: The aim of this study was to investigate cytomorphological and cytopathological changes in oral exfoliated smears collected from immunosuppressed patients with Behçet s disease (BD) using stereological methods. Materials and methods: For cytomorphometric analysis, mucosal cell smears were obtained from the buccal mucosa and the floor of the mouths of BD patients treated with immunosuppressive drugs and from healthy volunteers. All mucosal smears from the patients and the healthy volunteers were stained using the Papanicolaou method and examined cytopathologically under light microscopy and cytomorphologically via the stereological nucleator method. Results: The cytomorphological analysis revealed 3 types of mucosal cells, with numbers of particularly pink cells lower in the aphthous areas of the patients with BD compared to the healthy controls (P 0.05). There was lower apoptotic activity in the nondrug-use patients with BD and in the immunosuppressive-taking BD patients. Conclusion: The findings suggest that quantifiably morphological and morphometric changes in oral mucosa can be detected by stereological techniques. Changes in these parameters may indicate malignant transformation in the oral mucosa.

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Cite This Article

AKDENİZ, N., BİLEN, H., DOĞAN, H., ATEŞ, O., EYERCİ, N., KELEŞ, S., DİYARBAKIR, E., SELLİ, J., KARA, A. (2022). Effects of immunosuppressive drugs on oral mucosa in patients with Behçet?s disease: cytomorphological and cytopathological assessment. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 1, 145–151. https://ajindex.com/articles/610819

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