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Journals / Turkish Journal of Immunology / 2019 / Cilt: 7 - Sayı: 2

Increased Level of Interleukin-17 in Children and Adolescents with Type 1 Diabetes Mellitus and its Association with Vitamin D Deficiency

Tip 1 Diabetes Mellitus’lu Çocuk Ergen Hastalarda Artmış İnterlökin 17 ve Bu Artışın D Vitamini ile İlişkisi

Harjoedi Adji TJAHJONO
Leny Silviana FARIDA
Pages
76–82
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Blood samples were collected and serum vitamin D and IL-17 levels were measured by indirect ELISAwere.Results: The serum level of vitamin D serum and IL-17 level between both groups were significantly different(p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The up-regulation of interleukin-17 (IL-17) has been reported to be the pathogenesis of type 1 diabetesmellitus (T1D).
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Key Findings & Data:On the other hand, vitamin D deficiency is fairly prevalent in T1D.
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Conclusion & Impact:Blood samples were collected and serum vitamin D and IL-17 levels were measured by indirect ELISAwere.Results: The serum level of vitamin D serum and IL-17 level between both groups were significantly different(p
🔬Design:Survey & Empirical Study
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: The up-regulation of interleukin-17 (IL-17) has been reported to be the pathogenesis of type 1 diabetesmellitus (T1D). On the other hand, vitamin D deficiency is fairly prevalent in T1D. This study aims to investigateIL-17 and vitamin D status and its correlation in children and adolescents with T1D.Material and Methods: A cross sectional study was carried out between January to March 2017. A total of 20 patientsaged 12.25±3.74 years old with T1D and 20 healthy control group were involved. Their parents signed an informedconsent. Demographic data were obtained using structured questionnaires. Physical, and laboratory examination werealso performed. Blood samples were collected and serum vitamin D and IL-17 levels were measured by indirect ELISAwere.Results: The serum level of vitamin D serum and IL-17 level between both groups were significantly different(p

Özet

Giriş: Tip 1 Diabetes Mellitus (T1D)’un patogenezinde İnterlökin 17(IL-17)’nin artışının rolü olduğu bildirilmiştir. Öte yandan, T1D’lu hastalarda çoğunlukla D vitamini eksikliği saptanır. Bu çalışmada amaç, çocuk ve ergen T1D’li hastalarda IL-17 ve D vitamininin düzeylerini araştırmaktır. Gereçler ve Yöntemler: Çalışmada, 2017 Ocak ayı ile 2017 Mart ayı arasındaki hastalar çapraz kesitsel olarak irdelendi. Yaşları 12.25±3.74 arasında olan toplam 20 T1D’li olgu ile 20 sağlıklı birey kontrol grubu olarak çalışmaya dahil edildi. Hastaların ebeveynleri çalışmaya katılmak için bilgilenmiş onay verdi. Olguların demografik verileri oluşturulmuş anket formlarının doldurulması ile elde edildi. Ayrıca fizik muayene bulguları ve laboratuvar değerleri kaydedildi. Olgulardan kan alınarak indirekt ELISA yöntemi ile kan D vitamini ve IL-17 seviyeleri ölçüldü. Bulgular: D vitamini ve IL-17 seviyeleri 2 grup arasında karşılaştırıldığında istatistiksel olarak anlamlı derecede farklılık gözlendi (p

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Cite This Article

TJAHJONO, H. A., FARIDA, L. S. (2022). Increased Level of Interleukin-17 in Children and Adolescents with Type 1 Diabetes Mellitus and its Association with Vitamin D Deficiency. Turkish Journal of Immunology, Cilt: 7 - Sayı: 2, 76–82. https://ajindex.com/articles/607204

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References (1)

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