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Journals / Turkish Journal of Endocrinology and Metabolism / 2021 / Cilt: 25 - Sayı: 2

Plasma Levels of Soluble P-Selectin,Beta-Thromboglobulin and Platelet Indicesin Patients with Prediabetes:Effects of Acute Hyperglycemic Stress

Prediyabetik Hastalarda Oral Glukoz Yüklemesinin Trombositİndeks Değerleri ile Plazma P-Selektin ve Beta-Tromboglobülin Düzeyleri Üzerine Akut Etkisinin Araştırılması

Dildar KONUKOĞLU
Nesibe Esra YAŞAR
Pages
174–183
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Platelet count (PLT), mean platelet volume (MPV), platelet distri-bution width (PDW), and plateletcrit (PCT) were determined using the impedance method, and P-selectin and beta-thromboglobulin (β-TG) levels were determined by enzyme-linked immunosorbentassay.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To examine the effects of acute hyperglycemic stresson platelet activation by analyzing the plasma levels of P-selectin, beta-thromboglobulin, and platelet indices in an oral glucose to-lerance test (OGTT).
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Key Findings & Data:Material and Methods: The OGTT resultswere used to form four study groups: a control group (n=31) and a prediabetic group (n=103) comprising three subgroups accor-ding to the American Diabetes Association criteria for diabetes.
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Conclusion & Impact:Platelet count (PLT), mean platelet volume (MPV), platelet distri-bution width (PDW), and plateletcrit (PCT) were determined using the impedance method, and P-selectin and beta-thromboglobulin (β-TG) levels were determined by enzyme-linked immunosorbentassay.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To examine the effects of acute hyperglycemic stresson platelet activation by analyzing the plasma levels of P-selectin, beta-thromboglobulin, and platelet indices in an oral glucose to-lerance test (OGTT). Material and Methods: The OGTT resultswere used to form four study groups: a control group (n=31) and a prediabetic group (n=103) comprising three subgroups accor-ding to the American Diabetes Association criteria for diabetes. Platelet count (PLT), mean platelet volume (MPV), platelet distri-bution width (PDW), and plateletcrit (PCT) were determined using the impedance method, and P-selectin and beta-thromboglobulin (β-TG) levels were determined by enzyme-linked immunosorbentassay. P

Özet

Amaç: Çalışmamızın amacı, prediyabetik hastalarda plazma P-se- lektin ve beta-tromboglobülin düzeyleri ile trombosit indekslerinin ilişkisinin incelenmesi ve oral glukoz yüklemesi ile oluşturulan akuthiperglisemik stresin trombosit aktivasyon belirteçleri üzerine etki-sinin araştırılmasıdır. Gereç ve Yöntemler: Amerikan Diyabet Der- neği kriterlerine göre; oral glukoz tolerans testi sonuçları bazalınarak kontrol (n=31) ve prediyabet (n=103) grupları oluşturuldu.Oral glukoz yüklemesinden önce ve yüklemenin 2. saatinde alınankan örneklerinde trombosit sayısı [platelet count (PLT)], ortalamatrombosit hacmi [mean platelet volume (MPV)], trombosit dağılımgenişliği ve plateletkrit [plateletcrit (PCT)] impedans yöntemi ile P- selektin ve beta-tromboglobülin düzeyleri “Enzyme Linked İmmu- nabsorbent Assay” yöntemi ile belirlendi. İstatistiksel anlamlılıkp

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Cite This Article

KONUKOĞLU, D., YAŞAR, N. E. (2022). Plasma Levels of Soluble P-Selectin,Beta-Thromboglobulin and Platelet Indicesin Patients with Prediabetes:Effects of Acute Hyperglycemic Stress. Turkish Journal of Endocrinology and Metabolism, Cilt: 25 - Sayı: 2, 174–183. https://ajindex.com/articles/605299

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