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Journals / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 5

The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA

Mehmet Salih AĞIRTAŞ
Ali ARSLANTAŞ
Pages
1310–1320
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The results demonstrated that the octakisphenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative bindingmode.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide wassynthesized and characterized.
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Key Findings & Data:This interaction of CT-DNA with PcZn was investigated using electronic absorptionspectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurementsin a Tris-HCl buffer solution at a pH of 7.2.
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Conclusion & Impact:The results demonstrated that the octakisphenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative bindingmode.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide wassynthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of thezinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorptionspectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurementsin a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymusDNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study wasalso carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakisphenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative bindingmode.

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Cite This Article

AĞIRTAŞ, M. S., ARSLANTAŞ, A. (2022). The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 5, 1310–1320. https://ajindex.com/articles/601740

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