Journals / Sağlık Bilimleri Dergisi / 2018 / Cilt: 27 - Sayı: 1

ANTIMICROBIAL ACTIVITY AND THE PHENOLIC PROFILE OF FIVE SCROPHULARIA L. SPECIES

BEŞ SCROPHULARIA L. TÜRÜNÜN ANTIMIKROBIYAL AKTIVITESI VE FENOLIK PROFILI

Pages
10–15
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results of this study showed that furtherstudies were needed to identify the secondary metabolitesof the species and evaluate their antimicrobial activities.

📌 3 Key Takeaways

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Objective & Hypothesis:Scrophularia L. genus (Scrophulariaceae) has 310 taxaworldwide.
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Key Findings & Data:Our results revealed that all of the testedspecies contain caffeic acid and ferulic acid in variedconcentrations and none of them have chlorogenic acid.All of the plant species exhibited moderate activityagainst Candida albicans (MIC values; 0.3125 mg/mL).Besides, S. cinarescens exhibited moderate activityagainst Enterococcus faecalis (MIC value; 0.3125 mg/mL) and S. chrysantha exhibited moderate activityagainst Pseudomonas aeruginosa (MIC value; 0.3125mg/mL).
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Conclusion & Impact:The results of this study showed that furtherstudies were needed to identify the secondary metabolitesof the species and evaluate their antimicrobial activities.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Scrophularia L. genus (Scrophulariaceae) has 310 taxaworldwide. Some Scrophularia species are used in folkmedicine for the treatment of different skin inflammatorydiseases and as antibacterial. The aim of the studywas to investigate the antimicrobial activity and determinethe phenolic profile of S. kotscyhana Bentham, S.cinarescens Boiss., S. catariifolia Boiss. & Heldr., S. chrysanthaJaub&Spach and S. scopolii var. adenocalyxHoppe. ex Pers. Phenolic components were analyzed byan HPLC-DAD method. Disk diffusion method and microtiter-plateassay were used to determine the antimicrobialactivities of the aerial parts methanolic extractsof the species. Our results revealed that all of the testedspecies contain caffeic acid and ferulic acid in variedconcentrations and none of them have chlorogenic acid.All of the plant species exhibited moderate activityagainst Candida albicans (MIC values; 0.3125 mg/mL).Besides, S. cinarescens exhibited moderate activityagainst Enterococcus faecalis (MIC value; 0.3125 mg/mL) and S. chrysantha exhibited moderate activityagainst Pseudomonas aeruginosa (MIC value; 0.3125mg/mL). The results of this study showed that furtherstudies were needed to identify the secondary metabolitesof the species and evaluate their antimicrobial activities.

Özet

Scrophularia L. cinsi (Scrophulariaceae) dünya üzerinde 310 taksona sahiptir. Bazı Scrophularia türleri halk arasında çeşitli iltihaplı cilt hastalıklarının tedavisinde ve antibakteriyel olarak kullanılır. Çalışmanın amacı, S. kotscyhana Bentham, S. cinarescens Boiss., S. catariifolia Boiss. & Heldr., S. chrysantha Jaub&Spach ve S. scopolii var. adenocalyx Hoppe. ex Pers. türlerinin antimikrobiyal aktivitesini araştırmak ve fenolik profilini belirlemektir. Fenolik bileşenler bir HPLC-DAD yöntemi ile analiz edildi. Türlerin toprak üstü kısımlarının metanol ekstrelerinin antimikrobiyal aktivitelerini belirlemek için disk difüzyon yöntemi ve mikrodilüsyon yöntemi kullanıldı. Bulgularımız, test edilen tüm türlerin, çeşitli konsantrasyonlarda kafeik asit ve ferulik asit içerdiğini ve hiçbirinin klorojenik asit içermediğini ortaya koymuştur. Çalışılan tüm türler, Candida albicans'a (MIC değerleri; 0.3125 mg / mL) karşı orta derecede aktivite göstermiştir. Ayrıca, S. cinarescens, Enterococcus faecalis’e karşı (MIC değeri; 0.3125 mg/mL) ve S. chrysantha Pseudomonas aeruginosa’ya karşı (MIC değeri; 0.3125 mg/mL) orta derecede aktivite gösterdi. Bu çalışmanın sonuçları, türlerin sekonder metabolitlerinin aydınlatılması ve antimikrobiyal etkinliklerinin değerlendirilmesi için daha ileri çalışmalara ihtiyaç duyulduğunu gösterdi.

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Cite This Article

KORKMAZ, B., YILDIRIM, S., YAŞAR, A., TÜRKİŞ, S., SEVGİ, S., REİS, A., TOSUN, İ., RENDA, G., UZUNHİSARCIKLI, M. E., BEKTAŞ, N. Y. (2022). ANTIMICROBIAL ACTIVITY AND THE PHENOLIC PROFILE OF FIVE SCROPHULARIA L. SPECIES. Sağlık Bilimleri Dergisi, Cilt: 27 - Sayı: 1, 10–15. https://ajindex.com/articles/590102

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