AI Summary & Key Takeaways
AI InsightConclusion: Patients with iERM showed higher NLR compared to other groups. iERM might be accompanied by subclinical systemic infl ammation, whereas IMH might not be associated with systemic process.
📌 3 Key Takeaways
Abstract
Purpose: To evaluate the infl ammatory state in patients with idiopathic macular epiretinal membrane (iERM) and Idiopathic macular hole (IMH) by utilizing neutrophils/lymphocytes ratio (NLR). Method: We reviewed the medical records of the consecutive patients diagnosed with IMH or iERM retrospectively. Diagnosis was made by slit lamp fundus examination with a 90D lens and confi rmed by spectral domain optic coherence tomography (SD-OCT). The control group composed of consecutively selected patients who underwent cataract surgery. Complete blood count values were obtained from routine preoperative laboratory examination in study groups and control group. The NLR was calculated by dividing neutrophils count by lymphocytes count. Results: The present study enrolled 123 eyes of 123 consecutive patients, which consist of 42 eyes with iERM, 41 eyes with IMH, and 40 control eyes. Average NLR was markedly higher in the iERM group compared to other groups (both p=0.001). IMH and control group were similar with respect to mean NLR (p= 0.071). The AUROC value of the NLR to distinguish patients with iERM and control was found to be 0.847. The best cutoff value was 2.09, with a sensitivity of 77.8% and specifi city of 73.5%. Conclusion: Patients with iERM showed higher NLR compared to other groups. iERM might be accompanied by subclinical systemic infl ammation, whereas IMH might not be associated with systemic process.