Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 μM), which may be potential anti-inflammatory drugs.
📌 3 Key Takeaways
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Objective & Hypothesis:A new iridoid glycoside, cornusglucoside I (1), and a new natural product methyl 4-(3 ′ ,4 ′ - dihydroxyphenyl)-4-oxobutanoate (2), together with two known isolated compounds (3-4) were obtained from the 30% ethanol extract of the wine-processed Corni fructus.
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Key Findings & Data:The absolute configuration of 1 was elucidated by ECD calculation.
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Conclusion & Impact:Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 μM), which may be potential anti-inflammatory drugs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
A new iridoid glycoside, cornusglucoside I (1), and a new natural product methyl 4-(3 ′ ,4 ′ - dihydroxyphenyl)-4-oxobutanoate (2), together with two known isolated compounds (3-4) were obtained from the 30% ethanol extract of the wine-processed Corni fructus. Their structures were clarified by spectroscopic analysis and literature data. The absolute configuration of 1 was elucidated by ECD calculation. By evaluating the NO production induced by LPS in RAW 264.7 cells to assess the anti-inflammatory activities of isolated compounds. Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 μM), which may be potential anti-inflammatory drugs.
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Cite This Article
XU, E., WANG, Z., ZHANG, H., WANG, J., DAI, L., CHEN, S., ZHANG, L., FENG, Q., LI, H. (2022). A New Iridoid Glycoside from Wine-Processed Corni fructus. Records of Natural Products, Cilt: 16 - Sayı: 5, 409–416. https://ajindex.com/articles/588773
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