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Journals / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

Improved Anti-Atopic Dermatitis Effect of H. macrophylla through the Generation of Hydrangenol by Microwave Processing

Youngseok KİM
Dae-Hee LEE
Ha-Neul JU
Pilju CHOI
Taejung KIM
Young-Tae PARK
Jungyeob HAM
Pages
433–442
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion, microwave processing was found to be the optimal method for deglycosylation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The compounds hydrangenol and hydrangenol 8-O-glucoside are abundant in Hydrangea macrophylla.
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Key Findings & Data:This study investigated the effects of hydrangenol and hydrangenol 8-O-glucoside derived from H. macrophylla on atopic dermatitis (AD).
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Conclusion & Impact:Conclusion, microwave processing was found to be the optimal method for deglycosylation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The compounds hydrangenol and hydrangenol 8-O-glucoside are abundant in Hydrangea macrophylla. This study investigated the effects of hydrangenol and hydrangenol 8-O-glucoside derived from H. macrophylla on atopic dermatitis (AD). Compared with hydrangenol 8-O-glucoside, hydrangenol resulted in more potent inhibition of interleukin 4 (IL-4) gene expression and β-hexosaminidase release, as well as more potent inhibition of the phosphorylation of signal transducer and activator of transcription 6 (STAT6). Ultra High-Performance Liquid Chromatography (UHPLC), the concentrations of hydrangenol were found to be lower than the concentration of hydrangenol 8-O-glucoside in H. macrophylla extracts. To increase the hydrangenol content of H. macrophylla extract, component conversion methods were studied. Conclusion, microwave processing was found to be the optimal method for deglycosylation.

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Cite This Article

KİM, Y., LEE, D., JU, H., CHOI, P., KIM, T., PARK, Y., HAM, J. (2022). Improved Anti-Atopic Dermatitis Effect of H. macrophylla through the Generation of Hydrangenol by Microwave Processing. Records of Natural Products, Cilt: 16 - Sayı: 5, 433–442. https://ajindex.com/articles/588772

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