Moreover, compounds 2, 4 exhibited the significant activity in MDA-MB-231 cell lines with IC50 values 7.54 ± 1.50 and 7.23 ± 0.40 μΜ, respectively.
📌 3 Key Takeaways
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Objective & Hypothesis:A new neoflavonoid, (1R, 8R, 9R)-pterolinuse K (1) and six known neoflavonoids (2-7) were obtained from the heartwood of Dalbergia melanoxylon.
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Key Findings & Data:Compounds 3 and 6 showed anti-inflammatory activity with IC50 values 23.14 ± 0.30 and 19.46 ± 1.02 μΜ, respectively.
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Conclusion & Impact:Moreover, compounds 2, 4 exhibited the significant activity in MDA-MB-231 cell lines with IC50 values 7.54 ± 1.50 and 7.23 ± 0.40 μΜ, respectively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
A new neoflavonoid, (1R, 8R, 9R)-pterolinuse K (1) and six known neoflavonoids (2-7) were obtained from the heartwood of Dalbergia melanoxylon. The structure of the new neoflavonoid was elucidated by extensive NMR investigation, and X-ray crystallographic analysis. Compounds 3 and 6 showed anti-inflammatory activity with IC50 values 23.14 ± 0.30 and 19.46 ± 1.02 μΜ, respectively. Compounds 2-4, 6, 7 were showed cytotoxicity on Caco-2, MDA-MB-468, MDA-MB-231, CT26 cell lines. Moreover, compounds 2, 4 exhibited the significant activity in MDA-MB-231 cell lines with IC50 values 7.54 ± 1.50 and 7.23 ± 0.40 μΜ, respectively.
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Cite This Article
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