Journals / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 1

A New 2,3-Dioxygenated Flavanone and Other Constituents from Dysosma difformis

Pages
84–91
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The antioxidant and antidiabetic activities of the isolated compounds were evaluated.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A novel 2,3-dioxygenated flavanone, dysosmaflavanone (2), along with five known phenolic compounds including podophyllotoxin (1), podoverin A (3), kaempferol (4), 8,2′-diprenyl quercetin 3-methyl ether (5), and ethyl β-D-glucoside (6) were isolated from the roots of the plant Dysosma difformis.
📊
Key Findings & Data:Dysosmaflavanone, which possesses a rare 2,3-dioxygenated skeleton, could be regarded as an important chemotaxonomic marker.
💡
Conclusion & Impact:The antioxidant and antidiabetic activities of the isolated compounds were evaluated.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A novel 2,3-dioxygenated flavanone, dysosmaflavanone (2), along with five known phenolic compounds including podophyllotoxin (1), podoverin A (3), kaempferol (4), 8,2′-diprenyl quercetin 3-methyl ether (5), and ethyl β-D-glucoside (6) were isolated from the roots of the plant Dysosma difformis. Their structures were elucidated via spectroscopic analysis. Besides podophyllotoxin and kaempferol, the rest of the compounds were isolated from the genus Dysosma for the first time. Dysosmaflavanone, which possesses a rare 2,3-dioxygenated skeleton, could be regarded as an important chemotaxonomic marker. The antioxidant and antidiabetic activities of the isolated compounds were evaluated.

🔖

Cite This Article

HA, C. T. T., THANH, B. V., ANH, N. T. V., GIANG, D. H., LIEN, T. T., TUNG, N. K. T., DAT, N. T. (2022). A New 2,3-Dioxygenated Flavanone and Other Constituents from Dysosma difformis. Records of Natural Products, Cilt: 16 - Sayı: 1, 84–91. https://ajindex.com/articles/588745

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. C.V. Vo (2012). Dictionary of Vietnamese Medicinal Plants. Medicine Publisher, Hanoi, Vietnam
  2. M.L. Yin, Z.L. Chen, Z.S. Gu and Y.X. Xie (1989). Dysoanthraquinone and 2- demethyldysoanthraquinone from Dysosma majoense, Acta. Chim. Sin. 7, 468-470
  3. P.Z. Yu, L.P. Wang and Z.N. Chen (1991). A new podophyllotoxin-type lignan from Dysosma versipellis var. tomentosa, J. Nat. Prod. 54, 1422–1424
  4. Y. Zheng, Y.G. Xie, Y. Zhang, T. Li, H.L. Li, S.K. Yan, H.Z. Jin and W.D. Zhang (2016). New norlignans and flavonoids of Dysosma versipellis, Phytochem. Lett. 16, 75-81
  5. Y. Zheng, J. Ye, Y.G. Xie, H.L. Li and H.Z. Jin (2017). Chemical constituents of Dysosma versipellis, Chem. Nat. Compd. 53, 151-153
  6. X. Xu, X. Gao, L. Jin, P.S. Bhadury, K. Yuan, D. Hu, B. Song and S. Yang (2011). Antiproliferation and cell apoptosis-inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines, Cell. Div. 6, 14
  7. H. Ardalani, A. Avan and M.G. Mobarhan (2017). Podophyllotoxin: a novel potential natural anticancer agent, Avicenna J. Phytomed. 7, 285-294
  8. F. Liang, Y. Han, H. Gao, S. Xin, S. Chen, N. Wang, W. Qin, H. Zhong, S. Lin, X. Yao and S. Li (2015). Kaempferol identified by zebrafish assay and fine fractionations strategy from Dysosma versipellis inhibits angiogenesis through VEGF and FGF pathways, Sci. Rep. 5, 14468
  9. R.W. Jiang, J.R. Zhou, P.M. Hon, S.L. Li, Y. Zhou, L.L. Li, W.C. Ye, H.X. Xu, P.C. Shaw and P.P.H. But (2007). Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines, J. Nat. Prod. 70, 283-286
  10. J. Zhang, S.Y. Shi, M.J. Peng, J. Pan, H. Wan and C.S. Zhou (2014). Simultaneous determination of five active compounds from Dysosma difformis roots by HPLC, J. Liq. Chromatogr. Relat. Technol. 37, 1226-1236
  11. N.T. Dung, M.T. Long, B.H. Cuong and P.T. Thuong (2018). Flavonoids and lignans from the underground parts of Podophyllum tonkinense Gagnep. collected in Sa Pa and Lao Cai, Viet. Pharm. J. 7, 158
  12. W.B. Williams, M.E. Cuvelier and C. Berset (1995). Use of a free radical method to evaluate antioxidant activity, Lebensm. Wiss. Technol. 28, 25-30
  13. P.T. Thuong, N.D. Su, T.M. Ngoc, T.M. Hung, N.H. Dang, N.D. Thuan, K.H. Bae and W.K. Oh (2009). Antioxidant activity and principles of Vietnam bitter tea Ilex kudingcha, Food Chem. 113, 139- 145
  14. T.T.H. Hanh, N.M. Chau, L.H. Tram, N.T. Luyen, P.T. Binh, C.V. Minh, N.H. Nam and N.T. Dat (2013). Inhibition of α- gl