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Journals / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

Cytotoxic Drimane-type Sesquiterpenoids from the Fungus Aspergillus flavipes 297

Liancheng XU
Guodong LIU
Yu CHEN
Shan LIU
Weihuan LUO
Pengfei HU
Changming HUANG
Xiang JI
Shiping WANG
Guanyi CAO
Pages
488–492
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract: Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3).
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Key Findings & Data:Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data.
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Conclusion & Impact:In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Abstract: Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3). Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data. In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.

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Cite This Article

XU, L., LIU, G., CHEN, Y., LIU, S., LUO, W., HU, P., HUANG, C., JI, X., WANG, S., CAO, G. (2022). Cytotoxic Drimane-type Sesquiterpenoids from the Fungus Aspergillus flavipes 297. Records of Natural Products, Cilt: 16 - Sayı: 5, 488–492. https://ajindex.com/articles/588743

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