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Journals / Meandros Medical And Dental Journal / 2021 / Cilt: 22 - Sayı: 1

Effect of Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Interleukin-1beta and Interleukin-37 in Different Periodontal Diseases

Farklı Periodontal Hastalıklarda Cerrahisiz Periodontal Tedavinin DişEti Oluğu Sıvısı İnterlökin-1beta ve İnterlökin-37 Üzerine Etkisi

Hülya TOKER
Ömer POYRAZ
Emine PİRİM GÖRGÜN
Pages
110–118
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Both periodontitis groups exhibited significant improvement in clinical parameters (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Interleukin-37 (IL-37), which is a natural inhibitor of innate immunity, is correlated with chronic inflammation and some autoimmune diseases.
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Key Findings & Data:Proinflammatory cytokines, for example, interleukin-1beta (IL-1β), which plays a key part in the periodontium, can induce IL-37.
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Conclusion & Impact:Results: Both periodontitis groups exhibited significant improvement in clinical parameters (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Interleukin-37 (IL-37), which is a natural inhibitor of innate immunity, is correlated with chronic inflammation and some autoimmune diseases. Proinflammatory cytokines, for example, interleukin-1beta (IL-1β), which plays a key part in the periodontium, can induce IL-37. This study aimed to investigate the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF) IL37 and IL-1β levels in generalized aggressive periodontitis (G-AgP) and generalized chronic periodontitis (GCP). Materials and Methods: Thirty-five patients with G-AgP, 30 patients with GCP and 30 volunteers with healthy periodontal status (C) were included in this research. Patient groups received scaling and root planning with periodontal hand instrumentations. Clinical periodontal parameters and GCF samples were collected at baseline and at six weeks following SRP. Biomarker levels in GCF were analysed by enzyme-linked immunosorbent assay. Results: Both periodontitis groups exhibited significant improvement in clinical parameters (p

Özet

Amaç: Doğal bağışıklığın doğal bir inhibitörü olan interlökin-37 (IL-37), kronik enflamasyon ve bazı otoimmün hastalıklarla ilişkilidir. Periodonsiyumda önemli bir rol oynayan IL-1beta (IL-1β) gibi pro-enflamatuvar sitokinler, IL-37’yi indükleyebilir. Bu araştırmada, cerrahi olmayan periodontal tedavinin generalize agresif (G-AgP) ve generalize kronik periodontitiste (GCP) diş eti oluğu sıvısı (DOS) IL-37 ve IL-1β düzeyleri üzerine etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Otuz beş G-AgP hastası, 30 GCP hastası ve 30 periodontal olarak sağlıklı gönüllü (C) çalışmaya dahil edildi. Hasta gruplarına periodontal el aletleri ile detertraj ve kök yüzeyi düzleştirmesi uygulandı. Klinik periodontal parametrelerin ve DOS örneklerinin toplanması başlangıçta ve tedaviden 6 hafta sonra gerçekleştirildi. DOS’daki biyobelirteç seviyeleri enzim bağlı immünosorbent deneyi ile analiz edildi. Bulgular: Her iki periodontitis grubu da klinik parametrelerde anlamlı düzelme gösterdi (p

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Cite This Article

TOKER, H., POYRAZ, Ö., GÖRGÜN, E. P. (2022). Effect of Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Interleukin-1beta and Interleukin-37 in Different Periodontal Diseases. Meandros Medical And Dental Journal, Cilt: 22 - Sayı: 1, 110–118. https://ajindex.com/articles/578941

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