SavedAdd your journal

Journals / Meandros Medical And Dental Journal / 2022 / Cilt: 23 - Sayı: 1

The Effect of Niacin and Melatonin Supplementation on the Antioxidant System and Lipid Peroxidation in Exercised Rats

Egzersiz Yaptırılan Ratlarda Niasin ile Melatonin Takviyesinin Antioksidan Sistem ve Lipid Peroksidasyonu Üzerine Etkisi

Aslıhan BÜYÜKÖZTÜRK KARUL
Adem KESKİN
Pages
60–66
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These enzymes indicated that they were used in response to increased oxidant status.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to examine the effect of niacin and melatonin supplementation on the antioxidant system and lipid peroxidation in exercised rats.
📊
Key Findings & Data:Conclusion: Melatonin supplementation decreased malondialdehyde levels and increased antioxidant parameters.
💡
Conclusion & Impact:These enzymes indicated that they were used in response to increased oxidant status.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to examine the effect of niacin and melatonin supplementation on the antioxidant system and lipid peroxidation in exercised rats. Materials and Methods: The rats were divided into four groups. Running exercise was done for ten days. Niacin and melatonin were given before exercise. Results: The malondialdehyde levels of the melatonin group were lower than those of the other groups. Malondialdehyde levels of the niacin + melatonin group were higher than the control groups super oxide dismutase (SOD) levels of the melatonin group were higher than those of the other groups. SOD levels of the niacin + melatonin group were lower than those of the other groups. Catalase levels of the melatonin group were higher than those of the niacin groups. Glutathione peroxidase levels of the control group were lower than those of the other groups. Total oxidant levels of the control group were lower than those of the niacin groups. Total antioxidant level (TAS) levels of the control group were lower than those of the other groups. TAS levels of the niacin + melatonin group were lower than those of the niacin or melatonin groups. Melatonin levels of the melatonin groups were higher than those of the other groups. Conclusion: Melatonin supplementation decreased malondialdehyde levels and increased antioxidant parameters. It can be said that it has a higher antioxidant effect compared to niacin. Co-administration of niacin and melatonin increased oxidation parameters and decreased SOD and catalase levels. These enzymes indicated that they were used in response to increased oxidant status.

Özet

Amaç: Bu çalışmanın amacı, egzersiz yaptırılan ratlara verilen niasin ve melatonin desteğinin antioksidan sistem ve lipid peroksidasyonuna olan etkisini incelemektir. Gereç ve Yöntemler: Ratlardan 4 grup oluşturuldu. On gün koşu egzersizi yaptırıldı. Egzersiz öncesi niasin ve melatonin verildi. Bulgular: Melatonin grubunun malondialdehit düzeyleri, diğer gruplara göre daha düşüktü. Niasin + melatonin grubunun malondialdehit düzeyleri, kontrol grubuna göre daha yüksekti. Melatonin grubunun Süper oksit dismutaz (SOD) düzeyleri, diğer gruplara göre daha yüksekti. Niasin + melatonin grubunun SOD düzeyleri, diğer gruplara göre daha düşüktü. Melatonin grubunun katalaz düzeyleri, niasin gruplarına göre daha yüksekti. Kontrol grubunun glutatyon peroksidaz düzeyleri, diğer gruplara göre daha düşüktü. Kontrol grubunun total oksidan seviye düzeyleri, niasin gruplarına göre daha düşüktü. Kontrol grubunun total antioksidan seviye (TAS) düzeyleri, diğer gruplara göre daha düşüktü. Niasin + melatonin grubunun TAS düzeyleri, niasin veya melatonin gruplarına göre daha düşüktü. Melatonin gruplarının melatonin düzeyleri diğer gruplara göre daha yüksekti. Sonuç: Melatonin takviyesi, malondialdehit düzeylerini azalttı ve antioksidan parametreleri artırdı. Niasine göre daha yüksek bir antioksidan etkiye sahip olduğu söylenebilir. Niasin ve melatoninin birlikte uygulanması oksidasyon parametrelerini arttırdı ve SOD ve katalaz seviyelerini azalttı. Bu enzimler, artan oksidan durumuna yanıt olarak kullanıldıklarını gösterdi.

🔖

Cite This Article

KARUL, A. B., KESKİN, A. (2022). The Effect of Niacin and Melatonin Supplementation on the Antioxidant System and Lipid Peroxidation in Exercised Rats. Meandros Medical And Dental Journal, Cilt: 23 - Sayı: 1, 60–66. https://ajindex.com/articles/578928

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Górnicka M, Drywień M, Frąckiewicz J, Dębski B, Wawrzyniak A. Alpha-Tocopherol May Protect Hepatocytes Against Oxidative Damage Induced by Endurance Training in Growing Organisms. Adv Clin Exp Med 2016; 25: 673-9
  2. Pialoux V, Mounier R, Ponsot E, Rock E, Mazur A, Dufour S, et al. Effects of exercise and training in hypoxia on antioxidant/prooxidant balance. Eur J Clin Nutr 2006; 60: 1345-54
  3. Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol 2015; 6: 524-51
  4. Alonso M, Collado PS, González-Gallego J. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. J Pineal Res 2006; 41: 8-14
  5. Brzezinski A. Melatonin in humans. N Engl J Med 1997; 336: 186- 95
  6. Ağırbaş Ö. Effects of Melatonin and Ascorbic Acid on DNA Damage and Oxidative Stress Emerging in Muscles in Rats on Which Intensive Exercise Stress Was Created. Erzurum. Atatürk University. 2013
  7. Burtis CA, Ashwood ER. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 5th Ed. 2010
  8. Ilkhani F, Hosseini B, Saedisommeolia A. Niacin and Oxidative Stress: A Mini-Review. J Nutri Med Diet Care 2016; 2: 1-6
  9. Pingitore A, Lima GP, Mastorci F, Quinones A, Iervasi G, Vassalle C. Exercise and oxidative stress: potential effects of antioxidant dietary strategies in sports. Nutrition 2015; 31: 916-22
  10. Aguiló A, Tauler P, Pilar Guix M, Villa G, Córdova A, Tur JA, et al. Effect of exercise intensity and training on antioxidants and cholesterol profile in cyclists. J Nutr Biochem 2003; 14: 319-25
  11. Ziaadini F, Aminae M, MahsaRastegar MM, Abbasian S, Memari AH. Melatonin Supplementation Decreases Aerobic Exercise Training Induced-Lipit Peroxidation and Malondialdehyde in Sedentary Young Women. Pol J Food Nutr Sci 2017; 67: 225-32
  12. Mohn A, Catino M, Capanna R, Giannini C, Marcovecchio M, Chiarelli F. Increased oxidative stress in prepubertal severely obese children: effect of a dietary restriction-weight loss program. J Clin Endocrinol Metab 2005; 90: 2653-8
  13. Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012; 15: 838-47
  14. Beck WR, Botezelli JD, Pauli JR, Ropelle ER, Gobatto CA. Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaust