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Journals / Meandros Medical And Dental Journal / 2026 / Volume: 23 Issue: 1

The Effect of Niacin and Melatonin Supplementation on the Antioxidant System and Lipid Peroxidation in Exercised Rats

Adem Keskin(ADNAN MENDERES UNIVERSITY)
Aslıhan Büyüköztürk Karul(AYDIN ADNAN MENDERES UNIVERSITY)
Pages
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Publication Date
2022-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These enzymes indicated that they were used in response to increased oxidant status.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to examine the effect of niacin and melatonin supplementation on the antioxidant system and lipid peroxidation in exercised rats.
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Key Findings & Data:Conclusion: Melatonin supplementation decreased malondialdehyde levels and increased antioxidant parameters.
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Conclusion & Impact:These enzymes indicated that they were used in response to increased oxidant status.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Exercise · melatonin · niacin

Abstract

Objective: The aim of this study was to examine the effect of niacin and melatonin supplementation on the antioxidant system and lipid peroxidation in exercised rats. Materials and Methods: The rats were divided into four groups. Running exercise was done for ten days. Niacin and melatonin were given before exercise. Results: The malondialdehyde levels of the melatonin group were lower than those of the other groups. Malondialdehyde levels of the niacin + melatonin group were higher than the control groups super oxide dismutase (SOD) levels of the melatonin group were higher than those of the other groups. SOD levels of the niacin + melatonin group were lower than those of the other groups. Catalase levels of the melatonin group were higher than those of the niacin groups. Glutathione peroxidase levels of the control group were lower than those of the other groups. Total oxidant levels of the control group were lower than those of the niacin groups. Total antioxidant level (TAS) levels of the control group were lower than those of the other groups. TAS levels of the niacin + melatonin group were lower than those of the niacin or melatonin groups. Melatonin levels of the melatonin groups were higher than those of the other groups. Conclusion: Melatonin supplementation decreased malondialdehyde levels and increased antioxidant parameters. It can be said that it has a higher antioxidant effect compared to niacin. Co-administration of niacin and melatonin increased oxidation parameters and decreased SOD and catalase levels. These enzymes indicated that they were used in response to increased oxidant status.

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Cite This Article

Keskin, A., Karul, A. B. (2022). The Effect of Niacin and Melatonin Supplementation on the Antioxidant System and Lipid Peroxidation in Exercised Rats. Meandros Medical And Dental Journal, Volume: 23 Issue: 1. https://doi.org/10.4274/meandros.galenos.2021.27048

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