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Journals / Kolon ve Rektum Hastalıkları Dergisi / 2008 / Cilt: 18 - Sayı: 2

Hereditary colorectal cancer and polyposis syndromes

Kalıtsal kolorektal kanser ve polipozis sendromları

Aras Emre CANDA
Cem TERZİ
Pages
53–62
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Current genetic pathogenesis, clinical manifestations and treatments of hereditary colorectal cancer and polyposis syndromes are summarized in this article.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Improvements in genetics contribute valuable information on the pathogenesis of hereditary colorectal cancer and polyposis syndromes.
📊
Key Findings & Data:Improvements in genetics contribute valuable information on the pathogenesis of hereditary colorectal cancer and polyposis syndromes.
💡
Conclusion & Impact:Current genetic pathogenesis, clinical manifestations and treatments of hereditary colorectal cancer and polyposis syndromes are summarized in this article.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Improvements in genetics contribute valuable information on the pathogenesis of hereditary colorectal cancer and polyposis syndromes. Current genetic pathogenesis, clinical manifestations and treatments of hereditary colorectal cancer and polyposis syndromes are summarized in this article.

Özet

Genetik alanındaki gelişmeler günümüzde kalıtsal kolorektal kanser ve polipozis sendromlarının patogenezine yeni bilgiler eklemiştir. Bu çalışmada kalıtsal kolorektal kanserler ve polipozis sendromlarının güncel genetik patogenezi, klinik özellikleri ve tedavi yaklaşımları özetlenmiştir.

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Cite This Article

CANDA, A. E., TERZİ, C. (2022). Hereditary colorectal cancer and polyposis syndromes. Kolon ve Rektum Hastalıkları Dergisi, Cilt: 18 - Sayı: 2, 53–62. https://ajindex.com/articles/575434

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References (18)

  1. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525–32
  2. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759–67
  3. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789–99
  4. Boland CR, Goel A. Somatic evolution of cancer cells. Semin Cancer Biol 2005;15:436–50
  5. Burt R, Neklason DW. Genetic testing for inherited colon cancer. Gastroenterology 2005;128:1696–716 6. Lynch HT, de la Chapelle A. Genomic medicine hereditary colorectal cancer. New Eng J Med 2003;348:919–32
  6. Mecklin JP. Frequency of hereditary colorectalcarcinoma. Gastroenterology 1987;93:1021–5
  7. Lynch HT, Krush AJ. Cancer Family Syndrome and Cancer Control. Surg Gynecol Obstetr 1971;132:247–50
  8. Jen J, Kim H, Piantadosi S, et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 1994;331:213-21
  9. Petersen S, Thames HD, Nieder C, et al. The results of colorectal cancer treatment by p53 status. Dis Colon Rectum 2001;44:322-33
  10. Herman JG, Umar A, Polyak K. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998;95:6870-5
  11. Botoman VA, Pietro M, Thirlby RC. Localization of colonic lesions with endoscopic tattoo. Dis Colon Rectum 1994;37:775-6
  12. Watson P, Lynch HT. Extracolonic cancer in hereditary nonpolyposis colorectal cancer. Cancer 1993;71:677–85
  13. Mecklin JP, J¨arvinen HJ. Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer). Cancer 1991;68:1109–12
  14. Aarnio M, Sankila R, Pukkala E, et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 1999;81:214–8
  15. Ward E, Jemal A, Cokkinides V, et al. Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin 2004;54:78-93
  16. Vasen HFA, Mecklin JP, Khan PM, Lynch HT. The International Collaborative Group on hereditary nonpolyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum 1991;34:424–5
  17. Vasen HF, Watson P, Mecklin J-P, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999;116:1453–6
  18. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl C