Journals / Klimik Dergisi / 2011 / Cilt: 24 - Sayı: 2

Antimicrobial resistance of Gram-negative bacteria isolated from lower respiratory tract specimens of hospitalized patients

Hastanede yatan hastaların alt solunum yolu örneklerinden izole edilen Gram-negatif bakterilerde antimikrobiyal direnç

Pages
112–115
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Implementation of effective treatment protocols based on sensitivity test results can be useful in preventing nosocomial lower respiratory infections caused by resistant Gram-negative bacteria.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to determine the distribution of the genera of Gram-negative bacteria isolated from lower respiratory tracts of patients treated as in-patients and to calculate the antibiotic resistance rates to guide empirical antibiotic therapy.
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Key Findings & Data:Methods: Samples taken from the lower respiratory tract and sent to the Bacteriology Laboratory at the Celal Bayar University Faculty of Medicine from January 2008 to December 2010 were retrospectively analyzed.
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Conclusion & Impact:Conclusions: Implementation of effective treatment protocols based on sensitivity test results can be useful in preventing nosocomial lower respiratory infections caused by resistant Gram-negative bacteria.
🔬Design:Research Article
📍Scope:2008 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to determine the distribution of the genera of Gram-negative bacteria isolated from lower respiratory tracts of patients treated as in-patients and to calculate the antibiotic resistance rates to guide empirical antibiotic therapy. Methods: Samples taken from the lower respiratory tract and sent to the Bacteriology Laboratory at the Celal Bayar University Faculty of Medicine from January 2008 to December 2010 were retrospectively analyzed. Results: A total of 853 Gram-negative bacteria were isolated from specimens of in-patients. The rates of carbapenem (85%) and multidrug resistance (47%) among A. baumannii were higher than those observed for P. aeruginosa (30% and 19.2%). Carbapenem resistance was not found among the bacteria of the family Enterobacteriaceae, while the highest rates of resistance were detected for ciprofloxacin and trimethoprim-sulfamethoxazole. Conclusions: Implementation of effective treatment protocols based on sensitivity test results can be useful in preventing nosocomial lower respiratory infections caused by resistant Gram-negative bacteria.

Özet

Amaç: Bu çalışmada, hastanemizde yatarak tedavi gören hastaların alt solunum yolu örneklerinden izole edilen Gram-negatif bakterilerin cinslere göre dağılımı ve antibiyotik direnç oranlarının belirlenerek, ampirik antibiyotik tedavisinin yönlendirilmesi amaçlanmıştır. Yöntemler: Ocak 2008-Aralık 2010 tarihleri arasında Celal Bayar Üniversitesi Tıp Fakültesi Hastanesi Bakteriyoloji Laboratuvarına gönderilen alt solunum yolu örnekleri retrospektif olarak incelenmiştir. Bulgular: Yatarak tedavi gören hastalara ait örneklerden 853 Gram-negatif bakteri izole edilmiştir. A. baumannii suşlarında karbapenem (%85) ve çoğul ilaç direnci oranları (%47), P. aeruginosa için saptanan oranlardan daha yüksek bulunmuştur (%30 ve %19.2). Enterobacteriaceae ailesine ait bakterilerde en yüksek direnç oranları siprofloksasine ve trimetoprim/sülfametoksazole karşı saptanırken, karbapenem direncine rastlanmamıştır. Sonuçlar: Duyarlılık test sonuçlarına dayanarak etkin tedavi protokollerinin uygulanmasının dirençli bakterilerin neden olduğu nozokomiyal alt solunum infeksiyonlarının önlenmesinde yararlı olacağı düşünülmüştür.

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Cite This Article

ECEMİŞ, T., KURUTEPE, S., SÜRÜCÜOĞLU, S., GAZİ, H., GÜRSEV, N. (2022). Antimicrobial resistance of Gram-negative bacteria isolated from lower respiratory tract specimens of hospitalized patients. Klimik Dergisi, Cilt: 24 - Sayı: 2, 112–115. https://ajindex.com/articles/573679

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