Journals / Klimik Dergisi / 2012 / Cilt: 25 - Sayı: 1

Investigation of norovirus infections in immunosuppressed and immunocompetent adults suffering from diarrhea

İmmünosüpresif tedavi alan ve immünokompetan ishalli erişkinlerde norovirus infeksiyonu sıklığının araştırılması

Pages
10–13
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We emphasize that, in order to prevent norovirus outbreaks, strict hand hygiene and environmental disinfection procedures should be applied in the clinical wards of immunosuppressed patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the prevalence of norovirus infections in immunosuppressed patients and in immunocompetent adults suffering from diarrhea.
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Key Findings & Data:Methods: Between January-June 2011, 94 patients with diarrhea receiving immunosuppressive therapy at the Hematology Clinic were investigated for norovirus infection.
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Conclusion & Impact:We emphasize that, in order to prevent norovirus outbreaks, strict hand hygiene and environmental disinfection procedures should be applied in the clinical wards of immunosuppressed patients.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the prevalence of norovirus infections in immunosuppressed patients and in immunocompetent adults suffering from diarrhea. Methods: Between January-June 2011, 94 patients with diarrhea receiving immunosuppressive therapy at the Hematology Clinic were investigated for norovirus infection. Ninety-four patients with diarrhea were selected as the control group. The norovirus antigen was investigated in fecal samples by ELISA. White blood cell (WBC) count, C-reactive protein (CRP), and creatinine levels in patient and control groups were determined. Results: A norovirus infection was detected in 36.2% (34/94) of immunosuppressed patients, and in 9.6% (9/94) of the control group. Norovirus infection was seen more frequently in immunosuppressed patients than immunocompetents (p=0.001). Mean WBC and CRP levels were found significantly higher in patients infected with the norovirus, however, the difference in creatinine levels was statistically insignificant. Conclusion: Noroviruses have been detected more frequently in immunosuppressed patients, compared to immunocompetent adults. We emphasize that, in order to prevent norovirus outbreaks, strict hand hygiene and environmental disinfection procedures should be applied in the clinical wards of immunosuppressed patients.

Özet

Amaç: Bu çalışmanın amacı, ishali olan immünosüprese hastalarda ve immünokompetan yetişkinlerde norovirus infeksiyonlarının sıklığını saptamaktır. Yöntemler: Ocak-Haziran 2011 tarihleri arasında Hematoloji Kliniğinde immünosüpresif tedavi gören 94 ishalli hasta norovirus infeksiyonu yönünden değerlendirildi. Kontrol grubu olarak ishal yakınmasıyla başvuran 94 erişkin hasta seçildi. Norovirus antijeni dışkı örneklerinde ELISA yöntemiyle araştırıldı. Hasta ve kontrol grubunda bulunanlarda lökosit sayısı, C-reaktif protein (CRP), serum kreatinin düzeyleri araştırıldı. Bulgular: Norovirus infeksiyonu immünosüpresif tedavi alan hastaların %36.2 (34/94)sinde, kontrol grubundakilerin ise %9.6 (9/94)sında tespit edildi. İmmünosüpresif tedavi alan grupta norovirus infeksiyonu immünokompetan bireylere göre daha sık görüldü (p=0.001). Norovirusla infekte grupta ortalama lökosit ve CRP değerleri, anlamlı oranda yüksek bulunurken, serum kreatinin değerlerinde anlamlı fark tespit edilmedi. Sonuçlar: Norovirusların immünosüprese hastalarda, immünokompetan yetişkinlere göre daha sık infeksiyon etkeni oldukları görüldü. İmmünosüprese hastaların bulundukları servislerde olası norovirus salgınlarından korunmak için el hijyenine ve yüzey dezenfeksiyonuna azami önem verilmesi vurgulandı.

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Cite This Article

HAYDAROĞLU, H. Ş., EKŞİ, F., PEHLİVAN, M., BAYRAM, A., DAĞCI, Ş. Y. (2022). Investigation of norovirus infections in immunosuppressed and immunocompetent adults suffering from diarrhea. Klimik Dergisi, Cilt: 25 - Sayı: 1, 10–13. https://ajindex.com/articles/573650

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