SavedAdd your journal

Journals / Turkish Journal of Hematology / 2019 / Cilt: 36 - Sayı: 1

Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival

Kemik İliği Nakli Yapılan Hastalarda Kardiyak Parametrelerin Değerlendirilmesi: Pulmoner Arter Basıncının Sağkalıma Etkisi

Mustafa PEHLİVAN
Ali Caner ÖZDÖVER
İlknur GÜNDEŞ
Melya Pelin KIRIK
Handan HAYDAROĞLU ŞAHİN
Murat SUCU
Pages
19–24
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this study was to investigatewhether systolic pulmonary artery pressure (PAP) is a marker foroverall survival (OS) in HSCT patients.Materials and Methods: In our study, 428 HSCT patients wereevaluated.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Hematopoietic stem cell transplantation (HSCT) is a choiceof treatment for malignant and non-malignant diseases.
📊
Key Findings & Data:The aim of this study was to investigatewhether systolic pulmonary artery pressure (PAP) is a marker foroverall survival (OS) in HSCT patients.Materials and Methods: In our study, 428 HSCT patients wereevaluated.
💡
Conclusion & Impact:Inpatients with autologous HSCT (auto-HSCT) (PAP >25 mmHg), it wasfound that the 5-year mortality rate was 48.6%, while in the othergroup (PAP
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Hematopoietic stem cell transplantation (HSCT) is a choiceof treatment for malignant and non-malignant diseases. After HSCT,some complications may develop in patients. Cardiac complicationsare particularly important. The aim of this study was to investigatewhether systolic pulmonary artery pressure (PAP) is a marker foroverall survival (OS) in HSCT patients.Materials and Methods: In our study, 428 HSCT patients wereevaluated. Ejection fraction (EF) and PAP values were investigatedduring symptom-oriented echocardiography in the pre-HSCT andpost-HSCT periods.Results: Pre-HSCT EF values were similar between the groups. Inpatients with autologous HSCT (auto-HSCT) (PAP >25 mmHg), it wasfound that the 5-year mortality rate was 48.6%, while in the othergroup (PAP

Özet

Amaç: Hematopoietik kök hücre transplantasyonu (HKHT) malign ve non-malign hastalıklarda kullanılan bir tedavi seçeneğidir. Nakil sonrasında bir çok komplikasyon gelişmektedir. Kardiyak komplikasyonlar önemli bir yer tutmaktadır. Bu çalışmanın amacı, sistolik pulmoner arter basıncının (PAB) nakil yapılan hastaların sağkalımına olan etkisini araştırmaktır. Gereç ve Yöntemler: Çalışmamızda 428 HKHT yapılan hasta değerlendirildi. Ejeksiyon fraksiyonu (EF) ve PAB değerleri, semptom oryante ekokardiyografi ile post ve pretransplantasyon dönemde değerlendirildi. Bulgular: Karşılaştırılan gruplar arasında pre-HKHT döneminde EF değerleri açısından farklılık saptanmadı. Beş yıllık mortalite otolog HKHT yapılan hastalarda PAB değeri 25 mmHg üzeri olanlarda %48,6, diğer grupta %25,5 olarak gözlendi ve istatistiksel olarak p

🔖

Cite This Article

PEHLİVAN, M., ÖZDÖVER, A. C., GÜNDEŞ, İ., KIRIK, M. P., ŞAHİN, H. H., SUCU, M. (2022). Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology, Cilt: 36 - Sayı: 1, 19–24. https://ajindex.com/articles/606668

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Ballen KK, Lazarus H. Cord blood transplant for acute myeloid leukaemia. Br J Haematol 2016;173:25-36
  2. Murbraech K, Smeland KB, Holte H, Loge JH, Lund MB, Wethal T, Holte E, Rösner A, Dalen H, Kvaløy S, Falk RS, Aakhus S, Kiserud CE. Heart failure and asymptomatic left ventricular systolic dysfunction in lymphoma survivors treated with autologous stem-cell transplantation: a national crosssectional study. J Clin Oncol 2015;33:2683-2691
  3. Lehmann S, Isberg B, Ljungman P, Paul C. Cardiac systolic function before and after hematopoietic stem cell transplantation. Bone Marrow Transplant 2000;26:187-192
  4. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A; Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, FunckBrentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P; ESC Committee for Practice Guidelines. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012;14:803- 869
  5. Kim J, Shapiro L, Flynn A. The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease. Pharmacol Ther 2015;151:8-15
  6. Pesto S, Begic Z, Prevljak S, Pecar E, Kukavica N, Begic E. Pulmonary hypertension - new trends of diagnostic and therapy. Med Arch 2016;70:303-307
  7. Parasuraman S, Walker S, Loudon BL, Gollop ND, Wilson AM, Lowery C, Frenneaux MP. Assessment of pulmonary artery pressure by echocardiography-A comprehensive review. Int J Cardiol Heart Vasc 2016;12:45-51
  8. Dandoy CE, Hirsch R, Chima R, Davies SM, Jodele S. Pulmonary hyperten