Journals / Klimik Dergisi / 2016 / Cilt: 29 - Sayı: 1

Methotrexate Intoxication and Systemic Herpes Simplex Virus Infection in a Kidney Transplant Patient With Seronegative Arthropathy

Seronegatif Artropatili Böbrek Nakli Hastasında Metotreksat İntoksikasyonu ve Sistemik Herpes Simpleks Virusu İnfeksiyonu

Pages
43–46
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

HSV 1 viremia was detected in the patient and the symptoms improved quickly with acyclovir.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Herpes simplex virus (HSV) 1 commonly causes local skin infection around the mouth and face.
📊
Key Findings & Data:In this article, a 53-year-old patient who applied to our hospital due to the rashes all over the body and apparent around the mouth, beside fever is presented.
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Conclusion & Impact:HSV 1 viremia was detected in the patient and the symptoms improved quickly with acyclovir.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Herpes simplex virus (HSV) 1 commonly causes local skin infection around the mouth and face. However, infection may become widespread and can be more severe especially in people with immunodeficiency. Methotrexate is an antiproliferative and antifolate drug which is used successfully in the treatment of chronic inflammatory diseases such as rheumatoid arthritis. On the other hand, it is associated with severe toxicity and side effects. In this article, a 53-year-old patient who applied to our hospital due to the rashes all over the body and apparent around the mouth, beside fever is presented. The patient who has been receiving methotrexate treatment because of rheumatoid arthritis had kidney transplantation five years ago. HSV 1 viremia was detected in the patient and the symptoms improved quickly with acyclovir.

Özet

Herpes simpleks virusu (HSV) 1 genellikle ağız çevresi ve yüzde lokal cilt infeksiyonuna neden olmaktadır. Ancak bazen, özellikle immün yetmezlikli kişilerde infeksiyon yaygın hale gelebilmekte ve daha ağır seyredebilmektedir. Metotreksat, romatoid artrit gibi kronik inflamatuar hastalıkların tedavisinde başarıyla kullanılan antiproliferatif bir folik asid antagonistidir. Diğer yandan, metotreksat birçok ciddi toksisite ve yan etkiyle ilişkilidir. Bu yazıda ağız çevresinde belirgin olan ve tüm vücuda yayılan döküntüler ve ateş nedeniyle hastanemize başvuran, romatoid artrit nedeniyle metotreksat tedavisi alan, beş yıl önce böbrek nakli yapılmış 53 yaşında bir olgu sunulmuştur. Hastada HSV 1 viremisi saptanmış ve asiklovir tedavisiyle klinik tablosu hızlı şekilde düzelmiştir.

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Cite This Article

SAĞLIK, İ., GÜMÜŞ, A., ULUKAL, E., CENGİZ, M., ÇOLAK, D., GÜNSEREN, F., YEŞİL, C. (2022). Methotrexate Intoxication and Systemic Herpes Simplex Virus Infection in a Kidney Transplant Patient With Seronegative Arthropathy. Klimik Dergisi, Cilt: 29 - Sayı: 1, 43–46. https://ajindex.com/articles/573571

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