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Journals / Journal of Neurological Sciences (Turkish) / 2007 / Cilt: 24 - Sayı: 4

Harekete ilişkin kortikal potansiyellerin erken evre alzheimer hastalığında nöropsikolojik testler ile korelasyonu

Movement related cortical potentials are correlated to neuropsychological tests in early alzheimer's disease

Görsev G. YENER
Meral OĞUZ
Gülden AKDAL
Müslüm YILMAZ
Pages
307–313
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our findings imply a loss of motor preplanning caused by deranged neuronal input into supplementary motor areas and sensorimotor areas, i.e. the generators of MRCP, in early AD.

📌 3 Key Takeaways

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Objective & Hypothesis:The movement related cortical potentials (MRCP) are a useful tool for investigating the planning of a motor activity.
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Key Findings & Data:The neuropsychological tests and MRCP were performed in 23 AD patients and 20 healthy aged controls.
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Conclusion & Impact:Our findings imply a loss of motor preplanning caused by deranged neuronal input into supplementary motor areas and sensorimotor areas, i.e. the generators of MRCP, in early AD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The movement related cortical potentials (MRCP) are a useful tool for investigating the planning of a motor activity. Before the movement, a negative cortical potential appears maximum amplitude over at frontal lobes. Alzheimer disease is the most common cause of dementia and cognitive deficits include those related to frontal lobes. In the present study, we investigated MRCP and whether a correlation between neuropsychological tests and MRCP exists in mild Alzheimer's disease (AD). The neuropsychological tests and MRCP were performed in 23 AD patients and 20 healthy aged controls. Patient group fulfilled the DSM-IV criteria for dementia and NINCDS-ADRDA criteria for probable AD. The MRCP and neuropsychological tests were compared in age- and gender-matched healthy controls. MRCP were abnormal in AD patients, Bereitshaftspotential and M1 amplitudes were significantly lower in AD patients (p< 0.05). MRCP alterations seen in patients correlate to neuropsychological tests. Our findings imply a loss of motor preplanning caused by deranged neuronal input into supplementary motor areas and sensorimotor areas, i.e. the generators of MRCP, in early AD.

Özet

Harekete ilişkin kortikal potansiyaller (HİKP) bir motor aktivitenin planlanmasını yansıtan yararlı bir yöntemdir. Hareketten önce frontal loblarda maksimum amplitüdde negatif kortikal potansiyal izlenir. Alzheimer hastalığı (AH) demanın en sık görülen nedeni olup, frontal lobla ilişkili kognitif bozukluklar gösterir. Bu çalışmada, HKİP ve nöropsikolojik testler arasında erken evre AH ile korelasyon bulunup bulunmadığını araştırıldı. Hasta grubu DSM-IV'e gore demans tanısına ve NINCDS-ADRDA kriterlerine gore olası AH'ye uyuyordu. HİKP ve nöropsikolojik testler yaşı ve cinsiyeti eşleştirilmiş sağlıklı kontrollerle karşılaştırıldı. HİKP AH hastalarında anormal bulundu. Bereitshaftspotential ve M1 amplitüdleri AH' de daha düşüktü (p

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Cite This Article

YENER, G. G., OĞUZ, M., AKDAL, G., YILMAZ, M. (2022). Harekete ilişkin kortikal potansiyellerin erken evre alzheimer hastalığında nöropsikolojik testler ile korelasyonu. Journal of Neurological Sciences (Turkish), Cilt: 24 - Sayı: 4, 307–313. https://ajindex.com/articles/565624

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