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Journals / Journal of Neurological Sciences (Turkish) / 2010 / Cilt: 27 - Sayı: 4

Alzheimer ve vasküler demanslı hastalarda Chlamydophila pneumonaie seroprevalansı

Seroprevalance of Chlamydophila pneumoniae in patients with Alzheimer's disease and vascular dementia

Nuri ÖZKÜTÜK
Hatice MAVİOĞLU
Sinem AKÇALI
Talat ECEMİŞ
Melek KARAÇAM
Tamer ŞANLIDAĞ
Pages
400–406
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found no serological evidence for a significant association between C. pneumoniae and Alzheimer's disease as well as vascular dementia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In recent years, it was been argued that Chlamydophila pneumoniae, which is an intracellular pathogen capable of causing chronic infection, might be effective in some forms of dementia, an argument confirmed or rejected by some studies.
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Key Findings & Data:We tested 54 patients with Alzheimer and 29 patients with vascular dementia and 50 controls for C. pneumoniae IgG and IgA antibodies and analyzed the results statistically.
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Conclusion & Impact:It was found no serological evidence for a significant association between C. pneumoniae and Alzheimer's disease as well as vascular dementia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In recent years, it was been argued that Chlamydophila pneumoniae, which is an intracellular pathogen capable of causing chronic infection, might be effective in some forms of dementia, an argument confirmed or rejected by some studies. The objective of this study was to determine if there was an association between C. pneumoniae infection and Alzheimer's disease and vascular dementia. We tested 54 patients with Alzheimer and 29 patients with vascular dementia and 50 controls for C. pneumoniae IgG and IgA antibodies and analyzed the results statistically. C. pneumoniae IgG antibodies were found in 25 patients (49.2%) with Alzheimer's disease, 15 patients (51.8%) with vascular dementia and 22 controls (44%) whereas 6 patients (11.1%), 2 patients (6.9%) and 3 controls (6%), respectively, tested positive for IgA. It was found no serological evidence for a significant association between C. pneumoniae and Alzheimer's disease as well as vascular dementia.

Özet

Son yıllarda, bir hücre içi patojeni olan ve kronik enfeksiyon yapabilen Chlamydophila pneumoniae'nın bazı demans türlerinde etkili olabileceği ileri sürülmüş, bunu doğrulayan yada çürüten çalışmalar yapılmıştır. Bu çalışmanın amacı C. pneumoniae enfeksiyonu ile Alzheimer ve vasküler demans hastalıkları arasında bir ilişki olup olmadığını serolojik olarak incelemektir. 54 Alzheimer, 29 vasküler demanslı hastada ve 50 kontrolde C. pneumoniae IgG ve IgA antikorlarını araştırdık ve sonuçları istatistiksel olarak karşılaştırdık. C. pneumoniae IgG, Alzheimer'lı hastaların 25'inde (%49.2), vasküler demanslı hastaların 15'inde (%51.8) ve kontrollerin 22'sinde (%44) bulunurken, IgA için sırasıyla 6 (%11.1), 2 (%6.9) ve 3 (%6) pozitiflik tespit edildi. Bu çalışmada, Alzheimer ve vasküler demansla C. pneumoniae arasındaki anlamlı bir ilişki için serolojik bir kanıt bulunmadı.

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Cite This Article

ÖZKÜTÜK, N., MAVİOĞLU, H., AKÇALI, S., ECEMİŞ, T., KARAÇAM, M., ŞANLIDAĞ, T. (2022). Alzheimer ve vasküler demanslı hastalarda Chlamydophila pneumonaie seroprevalansı. Journal of Neurological Sciences (Turkish), Cilt: 27 - Sayı: 4, 400–406. https://ajindex.com/articles/565416

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