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Journals / Journal of Neurological Sciences (Turkish) / 2010 / Cilt: 27 - Sayı: 2

İzole sıçan sural sinirlerinde 4-aminopiridin tetiklemeli potansiyellere okskarbazepin'in etkisi

The effects of oxcarbazepine on 4-aminopyridine-induced afterpotentials on isolated rat sural nerves

Filiz KOÇ
Yakup SARICA
Hacer BOZDEMİR
Mustafa GÜVEN
İbrahim KAHRAMAN
İsmail GÜNAY
Pages
139–148
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Effects of oxcarbazepine at 0.1- 0.8 mM on the nerve conduction and 4-aminopyridine (4-ap) induced depolarizing after potentials were investigated.Results: All concentrations of oxcarbazepine exerted a significant concentration- and frequency dependent reduction in the amplitude of CAP, and prolonged the rising and the ½ falling phase of the CAP (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Oxcarbazepine is used for the treatment of neuropathic pain syndromes.
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Key Findings & Data:In the present study, we have investigated the effect of oxcarbazepine on the amplitude of compound action potentials (CAP), and the depolarizing after-potentials induced by 4-aminopyridine in the rat sural nerves which plays an important role of the neuropathic pain.Material and Method: The experiments were conducted with sucrose-gap technique, which is an electrophysiological method on the isolated wistar rat sural nerves.
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Conclusion & Impact:Effects of oxcarbazepine at 0.1- 0.8 mM on the nerve conduction and 4-aminopyridine (4-ap) induced depolarizing after potentials were investigated.Results: All concentrations of oxcarbazepine exerted a significant concentration- and frequency dependent reduction in the amplitude of CAP, and prolonged the rising and the ½ falling phase of the CAP (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Oxcarbazepine is used for the treatment of neuropathic pain syndromes. In the present study, we have investigated the effect of oxcarbazepine on the amplitude of compound action potentials (CAP), and the depolarizing after-potentials induced by 4-aminopyridine in the rat sural nerves which plays an important role of the neuropathic pain.Material and Method: The experiments were conducted with sucrose-gap technique, which is an electrophysiological method on the isolated wistar rat sural nerves. Effects of oxcarbazepine at 0.1- 0.8 mM on the nerve conduction and 4-aminopyridine (4-ap) induced depolarizing after potentials were investigated.Results: All concentrations of oxcarbazepine exerted a significant concentration- and frequency dependent reduction in the amplitude of CAP, and prolonged the rising and the ½ falling phase of the CAP (P

Özet

Amaç: Okskarbazepin nöropatik ağrıların tedavisinde kullanılan bir ilaçtır. Sıçan sural sinirlerinde yapılan bu çalışmada, okskarbazepin'in bileşik sinir aksiyon potansiyeli (BAP) amplitüdüne ve nöropatik ağrılarda önemli bir rolü olan depolarize edici art potansiyellere etkisi incelendi.Materyal ve Metod: Araştırmalar, elektrofizyolojik bir yöntem olan sukroz-gap tekniği ile Wistar türü sıçanların izole sural sinirlerinde yapıldı. 0,1, 0,2, 0,4 ve 0,8 mM konsantrasyonlarındaki okskarbazepin'in, BAP ve 2 mM 4-aminopiridin (4-ap) ile oluşturulan art potansiyellere etkisi araştırıldı.Bulgular: Okskarbazepin tüm konsantrasyonlarında BAP genliğini konsantrasyon-frekans bağımlı olarak anlamlı azaltarak yükselme ve ½ düşme süresini uzattı (P

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Cite This Article

KOÇ, F., SARICA, Y., BOZDEMİR, H., GÜVEN, M., KAHRAMAN, İ., GÜNAY, İ. (2022). İzole sıçan sural sinirlerinde 4-aminopiridin tetiklemeli potansiyellere okskarbazepin'in etkisi. Journal of Neurological Sciences (Turkish), Cilt: 27 - Sayı: 2, 139–148. https://ajindex.com/articles/565406

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