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Journals / Journal of Neurological Sciences (Turkish) / 2014 / Cilt: 31 - Sayı: 1

Vitamin B12 Eksikliği Olan Nörolojik Açıdan Asemptomatik Hastalarda Elektrodiagnostik Çalışmalar

Electrodiagnostic Studies in Neurologically Asymptomatic Patients with Vitamin B12 Deficiency

Tülin TANRIDAĞ
Füsun Mayda DOMAÇ
Mehmet GENCER
Geysu KARLIKAYA
Önder US
Yılmaz ÇETİNKAYA
Pages
1–10
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The electrophysiological findings may be normal in asymptomatic patients withvitamin B12 deficiency if the diagnosis is made early.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of our study was to investigate the electrophysiologic parameters inneurologically asymptomatic patients with vitamin B12 deficiency, and to compare the resultswith the control group and also to investigate a correlation between vitamin B12 levels andthe recorded parameters.Methods: Asymptomatic and untreated patients with vitamin B12 deficiency were examinedby nerve conduction studies, visual evoked potentials (VEPs), medial and tibialsomatosensory evoked potentials (SEPs), and motor evoked potentials (MEPs), prospectively.Patients who have any other disease that can effect nerve conduction studies, VEPs, SEPs,and MEPs were excluded.Results: Twenty-seven patients ( 22 women, 5 men) with a mean age of 37.65±13.08 and 21healthy subjects were examined.
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Key Findings & Data:The mean vitamin B12 level was 127±35.6 (N: 200-900) inthe patient group and 301±67 in the control group.
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Conclusion & Impact:The electrophysiological findings may be normal in asymptomatic patients withvitamin B12 deficiency if the diagnosis is made early.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of our study was to investigate the electrophysiologic parameters inneurologically asymptomatic patients with vitamin B12 deficiency, and to compare the resultswith the control group and also to investigate a correlation between vitamin B12 levels andthe recorded parameters.Methods: Asymptomatic and untreated patients with vitamin B12 deficiency were examinedby nerve conduction studies, visual evoked potentials (VEPs), medial and tibialsomatosensory evoked potentials (SEPs), and motor evoked potentials (MEPs), prospectively.Patients who have any other disease that can effect nerve conduction studies, VEPs, SEPs,and MEPs were excluded.Results: Twenty-seven patients ( 22 women, 5 men) with a mean age of 37.65±13.08 and 21healthy subjects were examined. The mean vitamin B12 level was 127±35.6 (N: 200-900) inthe patient group and 301±67 in the control group. There was not a statistically significantdifference between the patient and control groups according to nerve conduction studies,median SEP, tibial SEP, VEP, and MEP studies (p>0.05). There was no correlation betweenvitamin B12 levels and median SEP, tibial SEP, VEP, and MEP parameters (p>0.05).Conclusion: To our knowledge, this is the first study that has investigated neurologicallyasymptomatic patients with B12 deficiency by nerve conduction studies, VEPs, SEPs, andMEPs. The electrophysiological findings may be normal in asymptomatic patients withvitamin B12 deficiency if the diagnosis is made early.

Özet

Amaç: Çalışmamızın amacı vitamin B12 eksikliği olan nörolojik açıdan asemptomatikhastalarda elektrofizyolojik parametrelerin incelenmesi, sonuçların kontrol grubu ilekarşılaştırılması ve vitamin B12 düzeyleri ile kayıtlanan sonuçlar arasındaki korelasyonunaraştırılmasıdır.Metod: Vitamin B12 eksikliği olan asemptomatik ve tedavi edilmemiş hastalar prospektifolarak sinir ileti çalışmaları, görsel uyarılmış potansiyeller (VEP), medial ve tibialsomatosensoriel uyarılmış potansiyeller (SEP) ve motor uyarılmış potansiyeller (MEP)tetkikleri ile incelenmiştir. Sinir ileti çalışmaları, VEP, SEP ve MEP'leri etkileyebilecekhastalığı olanlar çalışma dışı bırakılmıştır.Bulgular: Yaş ortalaması 37.65±13.08 olan 27 hasta (22 kadın, 5 erkek) ile 21 sağlıklıgönüllü incelenmiştir. Ortalama vitamin B12 düzeyi hasta grubunda 127±35.6 pg/ml)(N: 200- 900pg/ml), kontrol grubunda 301±67pg/ml idi. Hasta ve kontrol grupları arasında sinir iletiçalışmaları, median SEP, tibial SEP, VEP ve MEP parametreleri açısından anlamlıistatistiksel fark saptanmadı (p>0.05). Vitamin B12 düzeyleri ile median SEP, tibial SEP,VEP ve MEP parametreleri arasında korelasyon bulunmadı (p>0.05).Sonuç: Bu çalışma vitamin B12 eksikliği olan nörolojik açıdan asemptomatik hastaları sinirileti çalışmaları, VEP, SEP ve MEP tetkikleriyle inceleyen ilk çalışmadır. Eğer tanı erkenkonulursa vitamin B12 eksikliği olan asemptomatik hastalarda elektrofizyolojik çalışmalarnormal olabilmektedir.

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Cite This Article

TANRIDAĞ, T., DOMAÇ, F. M., GENCER, M., KARLIKAYA, G., US, Ö., ÇETİNKAYA, Y. (2022). Vitamin B12 Eksikliği Olan Nörolojik Açıdan Asemptomatik Hastalarda Elektrodiagnostik Çalışmalar. Journal of Neurological Sciences (Turkish), Cilt: 31 - Sayı: 1, 1–10. https://ajindex.com/articles/565056

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