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Journals / Journal of Clinical and Analytical Medicine / 2014 / Cilt: 5 - Sayı: 6

Üzüm Çekirdeği Proanthocyanidin Özü (ÜÇPÖ) nün İdrar Sodyum Atılımı Üzerine Etkisi

The Effect of Grape Seed Proanthocyanidin Extract (GSPE) on Urinary Sodium Excretion

Mehmet ALKANAT
Şükrü ULUSOY
Asım ÖREM
Gülsüm ÖZKAN
Fulya YÜCESAN BALABAN
Pages
469–471
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Na excretion waspositively correlated with solid food intake (p=0.029, r=0.583) and urine vol- ume (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: While various hormones and mediators reduce the urinary excretion ofNa, other mediators such as nitric oxide (NO) increase Na excretion.
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Key Findings & Data:The control group was given 1 cm3milk by gavage for one week, while the GSPE group was given 100 mg/kgGSPE.
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Conclusion & Impact:Na excretion waspositively correlated with solid food intake (p=0.029, r=0.583) and urine vol- ume (p
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: While various hormones and mediators reduce the urinary excretion ofNa, other mediators such as nitric oxide (NO) increase Na excretion. Grapeseed proanthocyanidin extract (GSPE) is a molecule that has an antioxidanteffect by increasing NO levels. Our study was intended to evaluate the ef- fect of GSPE on Na excretion. Material and Method: Fourteen rats were divided into control and GSPE groups. The control group was given 1 cm3milk by gavage for one week, while the GSPE group was given 100 mg/kgGSPE. Seventh-day urines were collected from rats monitored over 24 h ina metabolic cage. Urinary Na excretion at the end of 24 h was investigatedand the experiment concluded. Results: There was no difference between thecontrol and GSPE groups in terms of weight, solid and liquid food intakeand urine volumes. 24-hour urinary Na excretion was higher in the GSPEgroup (1.43±0.30 g/day) compared to the control group (1.37±0.29 g/day),although the difference was not statistically significant. Na excretion waspositively correlated with solid food intake (p=0.029, r=0.583) and urine vol- ume (p

Özet

Amaç: Çeşitli hormon ve aracılar idrar Na atılımını azaltırken nitrik oksid (NO)gibi birtakım aracılar ise Na atılımını arttırmaktadır. Üzüm çekirdeği proant- hocynidin özü (ÜÇPÖ), NO düzeyini arttırarak antioksidan etki eden bir moleküldür. Çalışmamızda ÜÇPÖnin idrar Na atılımı üzerine etkisini değerlendirmeyi amaçladık. Gereç ve Yöntem: 14 adet rat kontrol ve ÜÇPÖ olmak üzere ayrıldı. Kontrol grubuna gavaj ile 1 hafta süreli 1 cm3 süt verilirken ÜÇPÖgrubuna 100mg/kg ÜÇPÖ verildi. 7. gün 24 saat süreli metabolik kafeste takip edilen ratların idrarları toplanıp 24 saatin sonunda idrar Na atılımı çalışıldı ve deney sonlandırıldı. Bulgular: Kontrol ve ÜÇPÖ gruplarının kilo, aldığıkatı ve sıvı gıda ve idrar volumleri arasında fark yoktu. 24 saatlik idrar Na atılımı ÜÇPÖ grubunda (1.43±0.30 gr/gün) kontrol grubuna (1.37±0.29 gr/gün)göre daha fazla idi ancak istatistiksel anlamlı değildi. Na atılımı ile katı gıdaalımı (p=0.029, r=0.583) ve idrar hacimleri (p

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Cite This Article

ALKANAT, M., ULUSOY, Ş., ÖREM, A., ÖZKAN, G., BALABAN, F. Y. (2022). Üzüm Çekirdeği Proanthocyanidin Özü (ÜÇPÖ) nün İdrar Sodyum Atılımı Üzerine Etkisi. Journal of Clinical and Analytical Medicine, Cilt: 5 - Sayı: 6, 469–471. https://ajindex.com/articles/561169

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