Journals / Journal of Clinical and Analytical Medicine / 2016 / Cilt: 7 - Sayı: 1

Akut Koroner Sendromda Sigara İçimi, Artmış İskemiModifiye Albumin Düzeyleri ile İlişkisizdir

Smoking is not Associated with Increased IschemiaModified Albumin Levels in Acute Coronary Syndrome

Pages
18–22
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In this study, smoking was found to have no effect on ischemia-modified albumin levels in patients with acute coronary syndrome.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Acute coronary syndrome (ACS) is a clinical condition that exists signs and symptoms with acute chest pain and myocardial ischemia.
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Key Findings & Data:Material and Method: 63 patients who met the acute coronary syndrome diagnosis criteria with no elevations of Troponin I, and 61 agematched control subjects were included in this study.
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Conclusion & Impact:In this study, smoking was found to have no effect on ischemia-modified albumin levels in patients with acute coronary syndrome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Acute coronary syndrome (ACS) is a clinical condition that exists signs and symptoms with acute chest pain and myocardial ischemia. Ischaemiamodified albumin (IMA) is a new diagnostic biochemical marker for acute coronary syndrome. It has been proposed that reactive oxygen species which occur in ischemia lead the formation of IMA. The aim of our study is to determine the levels of new cardiac ischemia marker IMA in ACS, the effect of smoking that is an event that leads to the formation of reactive oxygen species on IMA levels and the role of this effect on the interpretation of IMA results. Material and Method: 63 patients who met the acute coronary syndrome diagnosis criteria with no elevations of Troponin I, and 61 agematched control subjects were included in this study. Ischemia-modified albumin levels were determined with a colorimetric method. Results: Serum ischemia-modified albumin levels in the patient group were significantly higher compared to the control group (0.644 ± 0.168 vs. 0.534 ± 0.116, respectively). Although smokers have higher ischemia-modified albumin levels in the control and patient groups, this difference was not statistically different. Discussion: This is the first study evaluating the relationship between smoking and ischemia-modified albumin levels in acute coronary syndrome. In this study, smoking was found to have no effect on ischemia-modified albumin levels in patients with acute coronary syndrome.

Özet

Amaç: Akut koroner sendrom, akut göğüs ağrısı ve miyokard iskemisine bağlı gelişen semptomları içeren klinik bir durumdur. İskemi modifiye albumin (IMA) son yıllarda AKS tanısında kullanılmaya başlanan yeni bir belirteçtir. İskemi durumunda oluşan reaktif oksijen radikallerinin IMA oluşumuna neden olduğu saptanmıştır. Bizim çalışmamızın amacı, yeni bir kardiyak iskemi belirteci olan IMA'nın AKS'deki düzeylerini tespit etmek ve reaktif oksijen radikali oluşumuna neden olan sigara içiminin IMA düzeylerine etkisini ve bu etkinin, IMA düzeylerini değerlendirmedeki rolünü ortaya koymaktır. Gereç ve Yöntem: Troponin I yüksekliği olmadan akut koroner sendrom tanı kriterlerine sahip 63 hasta ve yaş olarak benzer 61 kontrol bireyi bu çalışmaya katılmıştır. İskemi modifiye albumin düzeyleri kolorimetrik metot ile ölçülmüştür. Bulgular: Hasta grubundaki serum iskemi modifiye albumin düzeyleri kontrol grubuna kıyasla anlamlı olarak yüksekti (Sırasıyla 0.644 ± 0.168 vs. 0.534 ± 0.116). Her ne kadar kontrol ve hasta grubunda sigara içenler daha yüksek iskemi modifiye albumin düzeylerine sahip olsalar da bu fark istatistiksel olarak anlamlı değildi. Tartışma: Bu çalışma, akut koroner sendromlu hastalarda sigara içimi ve iskemi modifiye albumin düzeyleri arasındaki ilişkiyi değerlendiren ilk çalışmadır. Bu çalışmada, akut koroner sendromlu hastalarda sigara içiminin iskemi modifiye albumin düzeyleri üzerine hiçbir etkisinin olmadığı saptanmıştır.

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Cite This Article

KARBEK, F. A., ÜSTÜNER, F., AKGÖL, E., ABUŞOĞLU, S., ARSLAN, B., ELLİDAĞ, H. Y. (2022). Akut Koroner Sendromda Sigara İçimi, Artmış İskemiModifiye Albumin Düzeyleri ile İlişkisizdir. Journal of Clinical and Analytical Medicine, Cilt: 7 - Sayı: 1, 18–22. https://ajindex.com/articles/560872

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