AI Summary & Key Takeaways
AI InsightThere was an inverse correlation between height SDS and time passed for normalization of serum TSH(r:- 0.51) and bone age delay (r:-0.68) and a positive correlation with serum T4 levels (r:0.59)(p
📌 3 Key Takeaways
Abstract
The growth data of 137 (90F.47M) children with congenital primary hypothyroidism (CPH) diagnosed prior to neonatal screening programme and followed for a mean duration of 8.7+4.4 years (2.3 -18.2) were analyzed retrospectively. CPH was due to thyroid aplasia in 43.8%, dyshormonogenesis in 31.4%, hypoplasia in 19.7% and ectopy in 5.1%. The children were divided with respect to age at diagnosis into Group 1 (30.6%) diag-nosed between 0-3 months, Group 2 (38.8%) between 3-12 months and Group 3 (30.6%) bet-ween 1 and 5 years of age. Group 1 had a significant better height standard deviation score (SDS) at the latest visit (0.6 + 0.5) than 2 (-0.4 ± 0.9) and 3 (-1,2 + 1.0). There was an inverse correlation between height SDS and time passed for normalization of serum TSH(r:- 0.51) and bone age delay (r:-0.68) and a positive correlation with serum T4 levels (r:0.59)(p
Özet
Kliniğimizde neonatal tarama programı uygulamaya başlamadan önce, farklı yaşlarda tanıları konulan konjenital primer hipotiroidili (KPH) 137 çocuğun (90K, 47E) büyüme verileri 8.7±4.4 yıllık bir izlem süresinde retrospektif değerlendirildi. Etiyoloji %43.8 aplazi, %31.4 dishormonogenez, %19.7 hipoplazi, %5.1 ektopi idi. Hastalar Grup 1: 0-3 ay (%30.6), Grup 2: 3-12 ay (%38.8), Grup 3: 1-5 yaş arası (% 30.6) tanı konanlar olarak 3 gruba ayrıldı. Son mua-yenede Grup l'in boy standart sapma (SDS) değeri (0.6 + 0.5), Grup 2 (-0.4 ± 0.9) ve Grup 3'den (-1.2 + 1.0) daha yüksek idi. Boy SDS ve tedavi sırasında TSH normalleşme süresi (r:-0.51) ve kemik yaşının (KY) geriliği (r:-0.68) arasında negatif; serum tiroksin (T4) düzeyi ile ise pozitif korelasyon vardı (r:0.59)(p