Journals / İstanbul Medical Journal / 2021 / Cilt: 22 - Sayı: 3

Histogram Analysis of Computed Tomography Images for Quantitative Assessment of Gastric Cancer Invasiveness

Mide Kanseri İnvazifliğinin Kantitatif Değerlendirmesinde Bilgisayarlı Tomografi Histogram Analizi

Pages
192–196
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Thus, histogramanalysis can be used preoperatively to evaluate serosalinvasion.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: To explore the role of computed tomography(CT) texture analysis in predicting T-stage of gastric cancers (GC).Methods: Preoperative enhanced CT images of 110 patients(men: 84, women: 26) with GC were reviewed retrospectively.Regions of interest were manually drawn along the margin ofthe lesion on the section where it appeared largest on the portalvenous CT images, which yielded texture parameters (1, 10,50, 90, and 99% percentiles; minimum, mean, and maximumnorm; variance; skewness, and kurtosis).
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Key Findings & Data:The diagnostic performance of CT texture parameters indifferentiating different stages was evaluated using receiveroperating characteristic analysis.Results: The T4 variance was significantly greater than that ofthe T1-to-T3 group (p˂0.05).
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Conclusion & Impact:Thus, histogramanalysis can be used preoperatively to evaluate serosalinvasion.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: To explore the role of computed tomography(CT) texture analysis in predicting T-stage of gastric cancers (GC).Methods: Preoperative enhanced CT images of 110 patients(men: 84, women: 26) with GC were reviewed retrospectively.Regions of interest were manually drawn along the margin ofthe lesion on the section where it appeared largest on the portalvenous CT images, which yielded texture parameters (1, 10,50, 90, and 99% percentiles; minimum, mean, and maximumnorm; variance; skewness, and kurtosis). Correlations betweentexture parameters and pathological stage were analysed withSpearman’s correlation test. The distributions of all variableswere checked with the aid of the Kolmogorov-Smirnov test.The Independent-Samples t-test and the Mann-Whitney Utest were used (as appropriate) to compare quantitative data.The chi-squared test was employed to compare qualitativedata. The diagnostic performance of CT texture parameters indifferentiating different stages was evaluated using receiveroperating characteristic analysis.Results: The T4 variance was significantly greater than that ofthe T1-to-T3 group (p˂0.05). The T4 skewness was significantlylower than that of the T1-to-T3 group (p˂0.05) but the T4kurtosis significantly higher (p˂0.05).Conclusion: The histogram parameters of CT-TA, especiallyskewness and kurtosis derived from portal, venous phase CTimages, may serve as biomarkers stratifying the risk of serosalinvasion (stage-T4) by locally advanced GC. Thus, histogramanalysis can be used preoperatively to evaluate serosalinvasion.

Özet

Amaç: Mide kanserlerinin (MK) T-evresini tahmin etmede bilgisayarlı tomografi (BT) doku analizinin rolünü keşfetmektir. Yöntemler: MK’li 110 hastanın (erkek: 84, kadın: 26) ameliyat öncesi geliştirilmiş BT görüntüleri retrospektif olarak incelendi. İlgi bölgeleri, doku parametreleri (1, 10, 50, 90 ve %99 persentiller; minimum, ortalama ve maksimum norm; varyans; çarpıklık ve basıklık). Doku parametreleri ile patolojik evre arasındaki ilişkiler Spearman korelasyon testi ile analiz edildi. Tüm değişkenlerin dağılımları Kolmogorov-Smirnov testi yardımıyla kontrol edildi. Niceliksel verileri karşılaştırmak için Independent-Samples t-test ve Mann-Whitney U testi (uygun şekilde) kullanıldı. Nitel verileri karşılaştırmak için ki-kare testi kullanılmıştır. Farklı aşamaları ayırt etmede CT doku parametrelerinin tanısal performansı, alıcı işletim karakteristiği analizi kullanılarak değerlendirildi. Bulgular: T4 varyansı, T1-T3 grubuna göre anlamlı derecede daha yüksekti (p˂0,05). T4 çarpıklığı, T1-T3 grubuna göre anlamlı derecede düşüktü (p˂0,05), ancak T4 basıklığı anlamlı derecede yüksekti (p˂0,05). Sonuç: BT doku analizi histogram parametreleri, özellikle portal, venöz faz BT görüntülerinden türetilen çarpıklık ve basıklık, lokal olarak ilerlemiş mide tümörlerinde serozal invazyon riskini (evre-T4) katmanlandıran biyobelirteçler olarak hizmet edebilir. Bu nedenle, histogram analizi, serozal invazyonu değerlendirmek için preoperatif olarak kullanılabilir.

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Cite This Article

MERMUT, Ö., YARDIMCI, A. H., BEKTAŞ, C. T., SEL, İ., YARDIMCI, V. H. (2022). Histogram Analysis of Computed Tomography Images for Quantitative Assessment of Gastric Cancer Invasiveness. İstanbul Medical Journal, Cilt: 22 - Sayı: 3, 192–196. https://ajindex.com/articles/551805

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