Journals / İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi / 2016 / Cilt: 23 - Sayı: 2

Can mean platelet volume have predictive value in premature retinopathy?

Prematüre retinopatisinde mean platelet volüm'un prediktif değeri olabilir mi?

Pages
185–191
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

During the second stage of the disease, while no difference was detected between the control and laser groups in terms of the thrombocytes count, (p=0.98, p>0.05), Significant differences were found in mean platelet volume values (p=0.001, p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Retinopathy of prematurity, a proliferative vitreoretinopathy resulting from the vascular disorder of the retina, is the most frequent cause of blindness in childhood.
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Key Findings & Data:Material and Methods: In our case-controlled study we have assessed 64 preterm cases at the risk of premature retinopathy, considering both the 46 preterm cases having been realized at the follow-up to need laser photocoagulation, and the first and second stage of the disease, in terms of thrombocytes, which play an important part in the transport and storage of vascular endothelial growth factor.
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Conclusion & Impact:During the second stage of the disease, while no difference was detected between the control and laser groups in terms of the thrombocytes count, (p=0.98, p>0.05), Significant differences were found in mean platelet volume values (p=0.001, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Retinopathy of prematurity, a proliferative vitreoretinopathy resulting from the vascular disorder of the retina, is the most frequent cause of blindness in childhood. In the pathogenesis of the disease, in particular, there are stages developing diametrically opposite to each other (the first phase vasoobliteration, the second phase neovascularization) helped our thoughts of the disease to form. Premature retinopathy is quite an important problem in newborn units not only as far as its consequences but also its follow-up and management. Our controlled clinical study aims to present a simple method that will facilitate the follow-up of the disease while guiding clinicians in predicting the prognosis of the disease. Material and Methods: In our case-controlled study we have assessed 64 preterm cases at the risk of premature retinopathy, considering both the 46 preterm cases having been realized at the follow-up to need laser photocoagulation, and the first and second stage of the disease, in terms of thrombocytes, which play an important part in the transport and storage of vascular endothelial growth factor. Results: No statistically significant difference was found between the control and laser groups in terms of the thrombocyte count and mean platelet volume values during the first stage of the disease (p>0.05). During the second stage of the disease, while no difference was detected between the control and laser groups in terms of the thrombocytes count, (p=0.98, p>0.05), Significant differences were found in mean platelet volume values (p=0.001, p

Özet

Amaç: Prematüre retinopatisi retinanın damarsal bozukluğu sonucu oluşan proliferatif vitreoretinopati olup çocuklardaki körlüklerin sık nedenlerindendir. Özellikle hastalık patogenezinde, birbirinin zıttı olarak gerçekleşen fazların (birinci faz-vasoobliteration, ikinci faz-neovascularization) olduğunun bulunması prematüre retinopatisi hakkındaki düşüncelerin şekillenmesine yardımcı olmuştur. Prematüre retinopatisi yenidoğan ünitelerinde sonuçları açısından olduğu kadar takibi ve tedavisi açısından da oldukça önemli bir problemdir. Biz kontrollü klinik çalışmamızda, hem hastalığın takibinde kolaylık sağlayacak hem de hastalığın prognozunun tahmin edilmesinde klinisyenlere yol gösterecek basit bir yöntemi gündeme getirmek istedik. Gereç ve Yöntemler: Biz vaka kontrollü çalışmamızda, ROP riski altındaki 64 preterm olguyu, takipleri sonucu lazer fotokoagülasyon ihtiyacı duyulmuş 46 preterm olgu ile hastalığın birinci ve ikinci fazlarını göz önünde bulundurarak, bu fazlarda önemli rol oynayan vasküler endotelyal growth faktörün taşınması ve depolanmasında rol oynayan trombositler açısından değerlendirdik. Bulgular: Hastalığın birinci fazında, trombosit sayıları ve ortalama trombosit hacmi değerleri açısından kontrol ve lazer grupları arasında istatistiksel bir fark bulunmadı (p>0.05). Hastalığın İkinci fazında da kontrol ve lazer grupları arasında trombosit sayıları açısından istatsitiksel bir fark bulunmazken (p=0.98, p>0.05), aynı fazdaki ortalama trombosit hacmi değerleri açısından ise anlamlı fark bulundu (p=0.001, p

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Cite This Article

KORKMAZ, L., BASTUG, O., GUNES, T., OZTURK, A., KARACA, C., OZDEMİR, A., KURTOGLU, S., KORKUT, S. (2022). Can mean platelet volume have predictive value in premature retinopathy?. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, Cilt: 23 - Sayı: 2, 185–191. https://ajindex.com/articles/549248

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