On treatment day 15, kidney tissues were removed for analysis.Results: TQ increased the total antioxidant status (TAS) and decreased creatinine (Cr), blood urea nitrogen (BUN), oxidative stress index (OSI) and total oxidant status (TOS) levels significantly (p
📌 3 Key Takeaways
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Objective & Hypothesis:Aim: The goal of the study is to examine the protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat kidneys.Material and Methods: Thirty five female Spraque-Dawley rats were divided into 5 groups (n=7): Control, OLZ, OLZ+TQ-1, OLZ+TQ-2, OLZ+TQ-3.
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Key Findings & Data:Two weeks administration of OLZ (4 mg/kg, once a day forthe first week, 8 mg/kg once a day for the second week, p.o.) was given to all groups, except control.
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Conclusion & Impact:On treatment day 15, kidney tissues were removed for analysis.Results: TQ increased the total antioxidant status (TAS) and decreased creatinine (Cr), blood urea nitrogen (BUN), oxidative stress index (OSI) and total oxidant status (TOS) levels significantly (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: The goal of the study is to examine the protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat kidneys.Material and Methods: Thirty five female Spraque-Dawley rats were divided into 5 groups (n=7): Control, OLZ, OLZ+TQ-1, OLZ+TQ-2, OLZ+TQ-3. All treatments were administered for two weeks by gavage. Two weeks administration of OLZ (4 mg/kg, once a day forthe first week, 8 mg/kg once a day for the second week, p.o.) was given to all groups, except control. TQ was administered (25, 50, 100 mg/kg, once daily) by gastric tube. On treatment day 15, kidney tissues were removed for analysis.Results: TQ increased the total antioxidant status (TAS) and decreased creatinine (Cr), blood urea nitrogen (BUN), oxidative stress index (OSI) and total oxidant status (TOS) levels significantly (p
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Cite This Article
OZER, M. K., TAŞTEMİR, D. K., BİLGİC, S., GÜVENC, A. N., KOCAMAN, N., AZİRAK, S. (2022). Olanzapine-induced renal damages and metabolic side effects: the protective effects of thymoquinone. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, Cilt: 25 - Sayı: 1, 70–75. https://ajindex.com/articles/549046
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