SavedAdd your journal

Journals / İnönü Üniversitesi Tıp Fakültesi Dergisi / 2002 / Cilt: 9 - Sayı: 1

Serum Beta2-Microglobulin: Its significance in the prediction of preeclampsia

Serum Beta2-Mikroglobülin: Preeklampsinin erken tahminindeki önemi

Önder ÇELİK
Aysun BAY
Şeyma HASÇALIK
Pages
49–52
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No difference between maternal serum ß$beta$2- microglobulin levels of two patients with preeclampsia and 13 patients who remained normotensive during gestation was found (1.01±0.10mg/L vs 1.00İ0.11 mg/L, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The study was planned to determine whether or not, second trimester maternal serum levels of $beta$2- microglobulin could be used to predict subsequent devolopment of preeclampsia Study design: Serum $beta$2-microglobulin levels of 7 nulliparous and 8 multiparous women with normotensive were determined nephelometrically.
📊
Key Findings & Data:Blood samples were collected between 18 and 26 weeks gestation and those cases were followed up prospectively for subsequent devolopment of preeclampsia.
💡
Conclusion & Impact:No difference between maternal serum ß$beta$2- microglobulin levels of two patients with preeclampsia and 13 patients who remained normotensive during gestation was found (1.01±0.10mg/L vs 1.00İ0.11 mg/L, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The study was planned to determine whether or not, second trimester maternal serum levels of $beta$2- microglobulin could be used to predict subsequent devolopment of preeclampsia Study design: Serum $beta$2-microglobulin levels of 7 nulliparous and 8 multiparous women with normotensive were determined nephelometrically. Blood samples were collected between 18 and 26 weeks gestation and those cases were followed up prospectively for subsequent devolopment of preeclampsia. Results: Mean maternal serum $beta$2-microglobulin levels of 15 normotensive pregnant patients were found 1.00+0.10 mg /L. Fifteen normotensive women were followed up prospectively, two of them (13.3%) preeclampsia developed and 13 women remained normotensive (86.7%) throughout pregnancy. No difference between maternal serum ß$beta$2- microglobulin levels of two patients with preeclampsia and 13 patients who remained normotensive during gestation was found (1.01±0.10mg/L vs 1.00İ0.11 mg/L, p

Özet

Amaç: Bu çalışma ikinci trimester maternal serum $beta$2-mikroglobülin düzeylerinin preeklampsi gelişiminin önceden saptanmasındaki prediktif değerini araştırmak için planlandı. Materyal Metod: Onsekiz ve 26. gestasyonel haftalar arasında gebeliği bulunan 7 nullipar ve 8 multipar olmak üzere toplam 15 normotansif hastanın maternal serum $beta$2-mikroglobülin düzeyleri nefelometrik olarak saptandı. Hastalar gebelikleri terme ulaşana kadar aylık olarak takip edildi. Yapılan takiplerinde preeklampsi gelişenler ile gelişmeyenlerin maternal serum $beta$2- mikroglobülin düzeyleri karşılaştırıldı. Bulgular: On beş hastanın ortalama maternal serum $beta$2-mikroglobülin düzeyleri 1.00±0.10 mg /L olarak saptandı. Bu hastaların yapılan takiplerinde sadece 2 hastada preeklampsi gelişirken (%13.3), 13 hasta normotansif olarak kaldı (%86.7). Preeklampsi gelişen 2 hastanın maternal serum $beta$2-mikroglobülin düzeyleri ile preeldampsi gelişmeyen 13 hastanın maternal serum $beta$2-mikroglobülin düzeyleri arasında herhangi bir fark bulunamadı (1.01±0.10mg/L, 1.00$pm$0.11 mg/L, p

🔖

Cite This Article

ÇELİK, Ö., BAY, A., HASÇALIK, Ş. (2022). Serum Beta2-Microglobulin: Its significance in the prediction of preeclampsia. İnönü Üniversitesi Tıp Fakültesi Dergisi, Cilt: 9 - Sayı: 1, 49–52. https://ajindex.com/articles/548948

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Shaarawy M, El Meleigy M, Rasheed K. Maternal serum transforming growth factor beta-2 in preeclampsia and eclampsia, a potential biomarker for the assessment of disease seventy and fetal outcome. J Soc Gynecol Investig. 2001;8:27-31
  2. Haddad B, Desvaux D, Livingston JC, Barranger E, Paniel BJ, Sibai BM. Failure of serum beta2-microglobulin levels as an early marker of preeclampsia. Am J Obstet Gynecol 2000;182:595-8
  3. Faden D, Tincani A. Tanzi P, Sparola L, Lojacono A, Tarantini M, Balestrieri G. Anti-beta2 glycoprotein antibodies are associated with some obstetrical complications, mainly preeclampsia-eclampsia. Eur J Obstet Gynecol Reprod Biol 1997:73:37-42
  4. Aune B, Vartun A, Oian P, Sagcr G. Evidence of dysfunctional beta2-adrenoceptor signal system in pre-eclampsia. BJOG 2000:107:116-21
  5. Tian G, Huang Q, Yu H. Clinical significance of changes of urinary enzymes in pregnancy induced hypertension. Zhonghua Pu Chan Ke Za Zhi 1996;31:465-7
  6. Katano K, Aoki A, Sasa II, Ogasawara M, Matsuura E, Yagami Y. Beta 2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum Reprod 1996:11:509-12
  7. Redline RW, Patterson P. Pre-eclampsia is associated with an excess of prolifcrative immature intermediate trophoblast. Hum Pathol 1995:26:594-600
  8. Erkkola R, Sjöberg NO. Can pre-eclampsia be predicted and prevented? Acta Obstet Gynecol Scan Supp 1997; 76:98-100
  9. Mushambi MC, Halligan AW, Williamson K. Recent developments in the pathophysiology and management of pre-eclampsia. Br J Anaesth 1996; 76:133-148
  10. Lockwood CJ, Rand JH. The immunobiology and obstetrical consequences of antiphospholipid antibodies. Obstet Gynecol Surv 1994;49:432-41
  11. Zahradnik HP, Mollcr K, Stumme H, Casper FW, Seufert R, Schafer W. Prostaglandins in the urine of hypertensive pregnant patients. Zentralbl Gynakol 1994;116:337-9 12. Zhang SJ. Urinary minor proteins, beta 2-microglobulin (beta 2-MG) assay with pregnancy induced hypertension. Zhonghua Fu Chan Ke Za Zhi 1993;28:706-8, 758 13. Yamamoto T, Yoshimura S, Geshi Y, Sasamori Y, Okinaga S, Kobayashi T, Mori H Measurement of antiphospholipid antibody by ELISA using purified beta2- glycoprotein I in preeclampsia. Clin Exp Immunol 1993;94:196-200 14. Saudan PJ, Parrell TJ, Brown MA. Bcta2-microglobulin in hypertensive pregnancies. Am J Kidney Dis 1998;31:308-12.