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Journals / İnönü Üniversitesi Tıp Fakültesi Dergisi / 2006 / Cilt: 13 - Sayı: 3

Sıçanlarda ovarektomi ve östrojen kullanımının dil mukozası üzerine olan etkileri

Effects of ovariectomy and estrogen replacement on rat tongue mucosa

M.Aydın KETANİ
Berna Güney SARUHAN
Pages
141–145
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: The findings demonstrate that in the rat, ovarian estrogens play an important role, and its deficiency possibly leads to the onset of tongue discomfort in ovariectomized rats.

📌 3 Key Takeaways

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Objective & Hypothesis:ABSTRACT: Objective: The aim of this study was to investigate the possible effect of sex steroid deficiency on the rat tongue mucosa as well as the effect of its replacement.
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Key Findings & Data:Methods: We chose 21 sexually virgin female Wistar albino rats in this study.
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Conclusion & Impact:Conclusions: The findings demonstrate that in the rat, ovarian estrogens play an important role, and its deficiency possibly leads to the onset of tongue discomfort in ovariectomized rats.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

ABSTRACT: Objective: The aim of this study was to investigate the possible effect of sex steroid deficiency on the rat tongue mucosa as well as the effect of its replacement. Methods: We chose 21 sexually virgin female Wistar albino rats in this study. We divided the model rats into 3 groups: Group-1:Control, Group-2: Sham-operated (bilaterally ovariectomized), and Group-3: Sham-operated, in addition we gave estrogen to Group-3. The tongue mucosa of ovariectomized rats was compared to that of control rats histologically. The same evaluation was also performed after hormone replacement therapy for the ovariectomized rats (Group-2,3). Results: We found that, the ovariectomized animals presented reduced thickness of the tongue epithelium with an irregular keratinized surface. The tongue epithelium thickness was increased after hormone replacement therapy. Conclusions: The findings demonstrate that in the rat, ovarian estrogens play an important role, and its deficiency possibly leads to the onset of tongue discomfort in ovariectomized rats.

Özet

ÖZET Amaç: Çalışmada amacımız, östrojen eksikliği oluşturulan ve bu eksikliğin giderilmesiyle sıçan dil mukozasında meydana gelen değişikliklerin araştırılmasıdır. Gereç ve Yöntem: Çalışmamızda 21 adet dişi erişkin Wistar albino cinsi sıçanlar kullanıldı. Sıçanlar, üç gruba ayrıldı. Grup-1: Kontrol grubu, Grup-2: Sham-operasyon(bilateral ovarektomi), Grup-3: Sham operasyon ve östrojen verilen grup idi. Kontrol grubu ile ovarektomi edilen grubun dil mukozası histolojik olarak karşılaştırıldı. Aynı karşılaştırılma işlemi, hormon kullanımından sonra ovarektomi gurubu ile de yapıldı (Grup-2, 3). Bulgular: Ovarektomi edilen sıçanların dil epitel yapılarının düzensiz, keratinize ve kalınlığında azalma olduğu gözlemlenmesine karşın; hormon kullanımından sonra epitel kalınlığının artışı gözlemlenmiştir. Sonuç: Bu bulgularımız, ovariumlardan salgılanan östrojenlerin önemli rolleri olduğunu ve eksikliklerinde dişilerde oral bozukluklara yol açabileceğini göstermektedir

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Cite This Article

KETANİ, M., SARUHAN, B. G. (2022). Sıçanlarda ovarektomi ve östrojen kullanımının dil mukozası üzerine olan etkileri. İnönü Üniversitesi Tıp Fakültesi Dergisi, Cilt: 13 - Sayı: 3, 141–145. https://ajindex.com/articles/548759

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